Examination of the differential characteristics of amplifier and contrasuppressor T cells

Immunobiology
P J BakerB Prescott

Abstract

Vicia villosa lectin-adherent Lyt-1+ spleen cells, obtained 4 days after immunization with an optimally immunogenic dose (0.5 micrograms) of Type III pneumococcal polysaccharide (SSS-III), increased the magnitude of the antibody response of mice to SSS-III upon transfer to recipients also immunized with the same antigen; however, the ability to demonstrate such enhancement depended greatly upon when such cells were transferred relative to immunization of recipients. Lectin-adherent cells augmented the antibody response of athymic nude (nu/nu) mice to SSS-III, and abrogated the expression - but not the induction - of low-dose immunological paralysis, a form of unresponsiveness mediated by suppressor T cells. These findings are consistent with effects usually attributed to the action of amplifier, rather than contrasuppressor, T cells.

References

Dec 1, 1985·Cellular Immunology·P J BakerB Prescott
Sep 1, 1983·The Journal of Experimental Medicine·M IversonR K Gershon
Jun 1, 1981·The Journal of Experimental Medicine·R K GershonD B Murphy

Related Concepts

pneumococcal polysaccharide, type III
Antibodies, Bacterial
B-Lymphocytes
Cell Adhesion
Lymphocyte Activation
Mice, Inbred BALB C
Polysaccharides, Bacterial
Spleen
T-Lymphocyte
Animal Lectins

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