Examination of the effect of a naturally occurring mutation in glycoprotein L on Marek's disease virus pathogenesis

Avian Diseases
Elizabeth R SantinMark S Parcells

Abstract

We recently reported a comparison of glycoprotein-encoding genes of different Marek's disease virus pathotypes (MDVs). One mutation found predominantly in very virulent (vv)+MDVs was a 12-bp (four-amino acid) deletion in the glycoprotein L (gL)-encoding gene in four of 23 MDV strains examined (three were vv+MDVs and one was a vvMDV). This mutation was noted in the gL of the TK (615K) strain, but not in the RL (615J) strain of MDV. These strains have identical mutations in the meq gene characteristic of vv+MDVs but can be distinguished by the mutation in the gL-encoding gene. The TK strain was originally isolated from vaccinated chickens and appeared to confer or enhance horizontal transmission of the vaccine virus, herpesvirus of turkeys (HVT). Because the molecular basis for increased virulence of MDV field strains is unknown, we hypothesized that one mechanism might be by coreplication of MDV-1 strains with HVT and that it could be mediated by the mutation of gL, an essential component of the glycoprotein H/L complex. In this study, we compared the pathogenicity of TK (615K) and RL (615J) strains of MDV in the presence and absence of simultaneous HVT coinfection. MDV infections were monitored at the levels of viremia (for bot...Continue Reading

References

May 1, 1978·Journal of the National Cancer Institute·K A Schat, B W Calnek
Sep 1, 1969·The British Veterinary Journal·B H RispensH J Maas
Jan 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·K NazerianB R Burmester
May 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sanjay M ReddyRichard L Witter
Nov 16, 2004·Journal of Virology·Lawrence PetherbridgeVenugopal K Nair
Sep 1, 2005·The Veterinary Journal·R L Witter
Jan 1, 1982·Avian Pathology : Journal of the W.V.P.A·K A SchatJ Fabricant

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Citations

Nov 6, 2010·Archives of Virology·Li-qiong TengZhi-zhong Cui
Jun 12, 2019·The Journal of General Virology·John R DunnHans H Cheng
Aug 2, 2013·Avian Diseases·Henry D Hunt, John R Dunn
Nov 25, 2020·Virology Journal·Shiro MurataKazuhiko Ohashi

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Methods Mentioned

BETA
PCR

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