Examination of the expression of cyclooxygenase-2 in placenta villi from sufferers of pregnancy induced hypertension

Biological & Pharmaceutical Bulletin
Masaki OkawaraSatoru Takeda

Abstract

The purpose of this paper is to elucidate the roles of phospholipase A(2) (PLA(2)), cyclooxygenase-2 (COX-2), and prostaglandin I(2) (PGI(2)) synthase in pregnancy induced hypertension (PIH). In placentas from normal pregnant women and pregnant women with severe PIH, the enzyme expression of PLA(2), COX-2, and PGI(2) synthase was measured using real time reverse transcription-polymerase chain reaction (RT-PCR). The expression of each enzyme was compared between normal (n=12) and PIH (n=12) groups. The expression levels of COX-2 and PGI(2) synthase during PIH pregnancy were significantly decreased to about 51% and 68%, respectively, of their values in normal pregnancy. However, the expression of PLA(2) was hardly changed by PIH. The decreases in COX-2 and PGI(2) synthase expression in severe PIH placentas may be causal factors in the disruption of the PGI(2)-thromboxane A(2) (TXA(2)) balance in favor of TXA(2). The decrease in COX-2 was more marked than that of PGI(2) synthase.

References

Feb 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K SatohH Sakamoto
Jun 1, 1985·American Journal of Obstetrics and Gynecology·S W Walsh
Oct 20, 2001·American Journal of Reproductive Immunology : AJRI·K FukushimaH Nakano
Aug 26, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·B BörekçiA Ozkan

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Citations

Sep 22, 2012·Microvascular Research·C WoolnoughA W Ashton
Jul 3, 2021·International Journal of Molecular Sciences·Monika BączkowskaMichał Ciebiera

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