Examination of the metabolite hydroxybupropion in the reinforcing and aversive stimulus effects of nicotine in rats

Psychopharmacology
E MalcolmMohammed Shoaib

Abstract

Preclinical studies with bupropion in rodent models of nicotine dependence have generated equivocal findings with regard to translating the clinical efficacy of the antidepressant as a smoking cessation agent. Given that rats are poor metabolizers of bupropion, the present experiments examined (2S,3S)-hydroxybupropion, the major active metabolite, on the positive reinforcing and aversive stimulus properties of nicotine in rats. In male hooded Lister rats, (2S,3S)-hydroxybupropion (1.0-10.0 mg/kg IP) was tested on intravenous nicotine (0.03 mg/kg/inf) self-administration behaviour for three sessions (n = 8), and in another experiment, the same doses of (2S,3S)-hydroxybupropion were tested in a conditioned taste aversion procedure to assess the aversive stimulus properties of nicotine, a function implicated in the regulation of nicotine intake. (2S,3S)-hydroxybupropion attenuated nicotine intake in a manner similar to that produced by mecamylamine pretreatment (1.0 mg/kg SC). This effect on nicotine-taking was specific since these doses had no effect on responding maintained by sucrose presented orally (200 μl of 5 % w/v). (2S,3S)-hydroxybupropion (1, 3 and 10 mg/kg IP) pretreatment failed to modify the aversive effects produced ...Continue Reading

References

Mar 1, 1987·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R M WelchD H Schroeder
Oct 1, 1994·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·B R CooperR M Ferris
Feb 1, 1997·Behavioral Neuroscience·P S Grigson
Feb 9, 2000·Psychopharmacology·S ShiffmanJ DeVeaugh-Geiss
Oct 18, 2001·Psychopharmacology·M S CousinsH de Wit
May 23, 2002·Experimental and Clinical Psychopharmacology·Jenny L WileyM Imad Damaj
Nov 27, 2002·Psychopharmacology·Mohammed ShoaibSajid Shafait
Jun 18, 2003·Psychopharmacology·Anthony S RauhutMichael T Bardo
Aug 12, 2003·European Journal of Pharmacology·Mikhail L BondarevRichard A Glennon
Aug 20, 2005·Addiction Biology·Charlotte Warner, Mohammed Shoaib
Nov 22, 2005·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Anthony S RauhutMichael T Bardo
Nov 19, 2008·Nebraska Symposium on Motivation·Anthony R CaggiulaAlan F Sved
Jun 26, 2010·The Journal of Pharmacology and Experimental Therapeutics·M Imad DamajF Ivy Carroll
May 17, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Sheri D GrabusMohamad Imad Damaj
Oct 27, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Kenneth A PerkinsErin Stratton
Nov 15, 2012·Clinical Pharmacology and Therapeutics·A Z X ZhuR F Tyndale
Feb 4, 2014·Advances in Pharmacology·F Ivy CarrollM Imad Damaj

❮ Previous
Next ❯

Citations

Jan 28, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Anna RickliMatthias E Liechti
Dec 4, 2019·Critical Reviews in Food Science and Nutrition·John Lewis Zinia ZaukuuZoltan Kovacs
Apr 3, 2020·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Pan-Fen WangEvan D Kharasch
May 10, 2020·Clinical Pharmacology and Therapeutics·Evan D KharaschEric J Lenze
May 15, 2018·Clinical Pharmacology and Therapeutics·Evan D Kharasch, Amanda Crafford
Mar 30, 2020·Neuropharmacology·Mohammed Shoaib, Kenneth A Perkins

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.