PMID: 15348641Sep 7, 2004Paper

Examination of the suitability of alpha-tocopherol as a stabilizer for ultra-high molecular weight polyethylene used for articulating surfaces in joint endoprostheses

Journal of Materials Science. Materials in Medicine
C WolfW Schneider

Abstract

The lifetime of articulating surfaces in joint endoprostheses made of ultra-high molecular weight polyethylene (UHMW-PE), especially of UHMW-PE-cups of hip-endoprostheses, is usually limited to 10-15 years due to material failure as a result of oxidation of the UHMW-PE in vivo. In this study the suitability of the natural antioxidant alpha-tocopherol (vitamin E) as a stabilizer for UHMW-PE in these applications was investigated. Specimens with 0.1%, 0.2%, 0.4% and 0.8% w/w alpha-tocopherol as well as unstabilized samples were sintered and sterilized with gamma-rays at 25 kGy in accordance with standard processing methods of cups for total hip-endoprostheses. These specimens were aged in pure oxygen at 70 degrees C and 5 bar as well as in aqueous H2O2 at 50 degrees C. The degree of oxidation was observed by means of FTIR-spectroscopy, DSC analysis and mechanical testing. The FTIR-measurements showed that alpha-tocopherol can prolong the lifetime of UHMW-PE in an oxidative environment by a factor of more than 2.5. In the mechanical tests no embrittlement could be observed with the stabilized samples. A comparison with the standard antioxidant system Irganox 1010/Irgafos 168 (Ciba-Geigy, Switzerland) was carried out and revealed t...Continue Reading

Citations

Oct 22, 2005·Clinical Orthopaedics and Related Research·Michael D Ries, Lisa Pruitt
Nov 7, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·M L Morrison, S Jani
Nov 3, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Satoshi TeramuraNaohide Tomita
Apr 27, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Giuliana BancheElena Maria Brach Del Prever
Nov 19, 2010·The Journal of Bone and Joint Surgery. American Volume·Bryan T JarrettHenrik Malchau
Sep 19, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Michael J Kasser
Dec 15, 2010·Clinical Orthopaedics and Related Research·Luis A GallardoMarkus A Wimmer
Sep 16, 2015·Journal of Functional Biomaterials·Antonio GiganteLorenzo Banci
Aug 11, 2016·JBJS Reviews·Theodore J GilbertKhaled J Saleh
May 17, 2011·Journal of Materials Science. Materials in Medicine·E Gómez-BarrenaJ A Puértolas
Dec 7, 2010·Clinical Orthopaedics and Related Research·Pierangiola Bracco, Ebru Oral
May 14, 2021·JBJS Reviews·Amit ParekhMark Gonzalez

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