Examination using LC-MS/MS determination of grayanotoxin levels in blood, urine, and honey consumed by patients presenting to the emergency department with mad honey intoxication and relations with clinical data: a preliminary study

Annals of Saudi Medicine
Ali AygunSuncheun Kim

Abstract

Intoxications related to "mad honey" are frequently encountered in the Black Sea region of Turkey. Intoxication is established on the basis of whether honey was consumed when history was taken at presentation. The search for a simple and reliable method for showing the grayanotoxins (GTXs) in mad honey in body fluids and in honey consumed by patients is still at the research stage. The purpose of this preliminary study was to investigate GTX levels in blood, urine, and honey consumed by patients with mad honey intoxication and to determine whether there is an association with clinical status. This descrptive study was conducted at the department of Emergency Medicine of Karadeniz Technical University Medical Faculty in Turkey. Mad honey, blood, and urine samples were obtained from patients between September 2013 and October 2014. Four cases presenting the Department of Emergency Medicine and diagnosed with mad honey intoxication were included in the study. GTX levels in blood, urine, and honey consumed by patients were determined using liquid chromatography-tandem mass spectrometry. Patients' mean blood GTX I level was 30.62 ng/mL, GTX III level 4.917 ng/mL, urine GTX I level 0.447 mg/mL, and GTX III level 1.998 mg/mL. The mean...Continue Reading

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Citations

Jun 9, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Hong Lak ChoiSun Moon Kim
Aug 4, 2018·Veterinary Pathology·Hannah PischonLars Mundhenk
Apr 2, 2019·Critical Reviews in Clinical Laboratory Sciences·Xander M R Van WijkJennifer M Colby
Nov 23, 2019·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Gulgun Cakmak-ArslanMeral Kekecoglu
Jul 1, 2020·Toxicon : Official Journal of the International Society on Toxinology·Shanti NassibouMagali Labadie

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