Examining a canine model of stunned myocardium with Gd-DTPA-enhanced MRI

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Rebecca E ThornhillJ Sykes

Abstract

It has previously been shown that the distribution volume of Gd-DTPA (lambda) in infarcted, canine myocardium is higher than that of normal tissue. The purpose of this study was to determine whether stunned myocardium exhibits increased lambda. Stunning was produced in beagles by means of 30 min LAD occlusion followed by 3 weeks (n = 4) reperfusion. Gd-DTPA was infused at each imaging session and lambda determined in vivo using a saturation recovery turboFLASH sequence; cine imaging was used to assess ventricular wall thickening (%WT). (201)Tl uptake was used as an independent assessment of viability. %WT data confirmed that the brief insult caused prolonged, yet reversible, regional contractile dysfunction in each animal. %WT was not significantly different from baseline values by 3 weeks post-reflow. Normal (201)Tl uptake confirmed the absence of infarction. The lambda of stunned tissue (lambda = 0.381 +/- 0.030 ml/g) was not elevated above that of normal tissue (lambda = 0.398 +/- 0.027 ml/g, P = NS), at any time point studied, in vivo. These data suggest that an increase in lambda is a specific indicator of irreversible damage.

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Citations

Oct 13, 2001·NMR in Biomedicine
Nov 7, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Kerry ThompsonR Terry Thompson
Jul 15, 2005·The International Journal of Cardiovascular Imaging·Kai Uwe JuergensWalter Heindel
Dec 26, 2003·Radiology·Gabriele A KrombachMichael F Wendland
Sep 11, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D D BellamyG Wisenberg
Mar 2, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rebecca E ThornhillAnya Sauer
Jan 8, 2014·Journal of Thoracic Imaging·Vishal SharmaBalazs Ruzsics
Mar 27, 2003·Journal of Cardiovascular Pharmacology·Kerry ThompsonGerald Wisenberg
Dec 5, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·B WilkF S Prato

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