Examining Huntington's disease patient and informant concordance on frontally mediated behaviors

Journal of Clinical and Experimental Neuropsychology
Danielle C Blinkoff HergertCynthia R Cimino

Abstract

Huntington's disease (HD) is a genetic, neurodegenerative disease that affects cognitive, psychiatric and motor functioning. Frontal subcortical circuits are impacted by disease pathology, resulting in frontally mediated behavioral dysfunction. The purpose of this study was (a) to examine the relationship between both patient and informant reports of frontally mediated behaviors and disease progression and (b) to determine rate of agreement between patient and informant reports of these behaviors in relation to disease progression. Twenty-six HD patients and their informants participated in the study at the University of South Florida. Patient-informant pairs completed the Frontal Systems Behavior Scale (FrSBe) Self and Family ratings forms, respectively. UHDRS (Unified Huntington's Disease Rating Scale) motor scores were obtained from medical records as an index of disease progression. Only informant report of frontally mediated behaviors of apathy, disinhibition, and executive dysfunction was related to neurological examination results. On average, ratings by patients with less severe motor symptoms were comparable to informant ratings, suggesting intact awareness of deficits. In contrast, ratings of patients with more severe...Continue Reading

References

Aug 1, 1991·Psychiatry Research·R S MarinS Firinciogullari
Mar 1, 1996·Movement Disorders : Official Journal of the Movement Disorder Society
Aug 21, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·J S PaulsenJ L Cummings
Mar 9, 2002·The Journal of Neuropsychiatry and Clinical Neurosciences·Jennifer C ThompsonDavid Neary
Apr 5, 2003·Assessment·Julie C StoutJane S Paulsen
Jun 1, 2004·The British Journal of Clinical Psychology·Linda Clare
Sep 24, 2005·The Journal of Neuropsychiatry and Clinical Neurosciences·Anjan ChatterjeeKaren S Marder
Oct 8, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Aileen K HoRoger A Barker
May 8, 2007·Biological Psychiatry·Kevin DuffUNKNOWN Predict-HD Investigators of the Huntington Study Group
May 15, 2007·Journal of Clinical and Experimental Neuropsychology·Karin F HothAntoine Bechara
Jan 5, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Rebecca E ReadyJane S Paulsen
Mar 12, 2008·The Neurologist·Raphael M Bonelli, Jeffrey L Cummings
Feb 3, 2009·The Clinical Neuropsychologist·George P Prigatano, Jeannine Morrone-Strupinsky
May 14, 2010·The Journal of Neuropsychiatry and Clinical Neurosciences·Kevin DuffUNKNOWN Predict-HD Investigators of the Huntington Study Group
Aug 24, 2011·Current Neurology and Neuroscience Reports·Jane S Paulsen
Jun 11, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Mari E Nurmi Laihosalo, Mervi Jehkonen

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Citations

Dec 17, 2016·Journal of Huntington's Disease·Jennifer A SimpsonGeorge J Yohrling
Nov 29, 2016·Journal of Clinical and Experimental Neuropsychology·Patricia L JohnsonCynthia R Cimino
Dec 29, 2017·Journal of the International Neuropsychological Society : JINS·Clare L KempnichJulie C Stout
Jul 20, 2019·The Clinical Neuropsychologist·Danielle C HergertCynthia R Cimino
Feb 28, 2020·The Journal of Neuropsychiatry and Clinical Neurosciences·Sarah GunnMaria Dale
Aug 2, 2019·Journal of Clinical Movement Disorders·Elvina May-Yin ChuCaroline Knight
Oct 18, 2016·Journal of Clinical and Experimental Neuropsychology·Matthew Calamia, John P K Bernstein
Mar 17, 2021·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Danielle C Hergert, Cynthia R Cimino

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