Examining interactions between genetic risk for alcohol problems, peer deviance, and interpersonal traumatic events on trajectories of alcohol use disorder symptoms among African American college students

Development and Psychopathology
Jinni SuDanielle M Dick

Abstract

Numerous studies have demonstrated that genetic and environmental factors interact to influence alcohol problems. Yet prior research has primarily focused on samples of European descent and little is known about gene-environment interactions in relation to alcohol problems in non-European populations. In this study, we examined whether and how genetic risk for alcohol problems and peer deviance and interpersonal traumatic events independently and interactively influence trajectories of alcohol use disorder symptoms in a sample of African American students across the college years (N = 1,119; Mage = 18.44 years). Data were drawn from the Spit for Science study where participants completed multiple online surveys throughout college and provided a saliva sample for genotyping. Multilevel growth curve analyses indicated that alcohol dependence genome-wide polygenic risk scores did not predict trajectory of alcohol use disorder symptoms, while family history of alcohol problems was associated with alcohol use disorder symptoms at the start of college but not with the rate of change in symptoms over time. Peer deviance and interpersonal traumatic events were associated with more alcohol use disorder symptoms across college years. Nei...Continue Reading

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Citations

Nov 20, 2018·Development and Psychopathology·José M Causadias, Dante Cicchetti
Apr 24, 2019·The Journal of Endocrinology·Patrycja A Jazwiec, Deborah M Sloboda
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Aug 3, 2019·Alcoholism, Clinical and Experimental Research·Albert J KsinanDanielle M Dick
May 8, 2021·Journal of Research on Adolescence : the Official Journal of the Society for Research on Adolescence·Alexander W O'DonnellJacqueline Homel

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