Examining the Bethesda criteria risk stratification of thyroid nodules

Pathology, Research and Practice
Ahmed DeniwarEmad Kandil

Abstract

The Bethesda criteria are proposed for appropriate stratification of malignancy risk in thyroid nodules, but controversy exists regarding their accuracy and reliability in decision making. Additionally, previous studies have suggested higher rates of both malignancy and false negative fine needle aspiration biopsy (FNA) associated with increasing nodule size. This study aims to determine the accuracy of ultrasound (US)-guided FNA using the current Bethesda criteria in surgical practice. We also aimed to investigate the relationship between nodule size and malignancy. A retrospective analysis of US-guided FNAs by a single surgeon during a 4.5 year period. FNA results using Bethesda criteria were compared to final surgical pathology. 611 patients with thyroid nodules underwent US-guided FNA. FNA results in 375 subsequently excised thyroid nodules were recorded according to the Bethesda criteria: 192 (51%) benign, 65 (17%) atypia of unknown significance/follicular lesion of undetermined significance (AUS/FLUS), 42 (11%), suspicious for follicular neoplasm (SFN), 17 (5%) suspicious for malignancy (SM), 28 (8%) malignancy, and 31 (8%) non-diagnostic. Malignancy was confirmed by surgical pathology in 15%, 34%, 50%, 88%, 100%, and 39%...Continue Reading

References

Feb 15, 1993·Annals of Internal Medicine·H Gharib, J R Goellner
Apr 10, 2004·Thyroid : Official Journal of the American Thyroid Association·Michael W YehOrlo H Clark
Jul 15, 2006·Thyroid : Official Journal of the American Thyroid Association·Mustafa CesurNuri Kamel
Nov 30, 2006·Journal of Surgical Oncology·Jennifer E Rosen, Michael D Stone
Dec 14, 2006·Advances in Surgery·Jennifer B OgilvieOrlo H Clark
Aug 25, 2007·Annals of Surgery·Karl Y BilimoriaCord Sturgeon
Dec 2, 2008·Surgery·John R PorterfieldThomas J Sebo
Oct 29, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid CancerR Michael Tuttle
Nov 6, 2009·Thyroid : Official Journal of the American Thyroid Association·Edmund S Cibas, Syed Z Ali
Nov 6, 2009·Thyroid : Official Journal of the American Thyroid Association·Constantine G A TheoharisDavid C Chhieng
Dec 31, 2010·Thyroid : Official Journal of the American Thyroid Association·Chung-Che Charles WangRichard B Lanman
May 24, 2011·Journal of the American College of Surgeons·John I LewCarmen C Solorzano
Jun 1, 2011·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Emad KandilBernard M Jaffe
Sep 1, 2011·Surgery·Melanie GoldfarbJohn I Lew
Dec 22, 2011·Yonsei Medical Journal·Ernest L Mazzaferri
Apr 25, 2012·World Journal of Surgery·Dhafir Al-azawiJulie A Miller
Dec 18, 2013·Thyroid : Official Journal of the American Thyroid Association·Allen S HoLuc G T Morris

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Citations

May 5, 2016·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Sarah KhalifeRichard J Payne
Dec 8, 2016·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·J Matthew DebnamBeth S Edeiken-Monroe
Apr 27, 2018·International Journal of Endocrinology and Metabolism·Beatriz Godoi CavalheiroClaudio Roberto Cernea
Dec 4, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Sandrine EstebeFranck Jegoux
Mar 2, 2021·Journal of Clinical & Translational Endocrinology·Adnan ZahidUmal Azmat

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