Examining the effects of HIV self-testing compared to standard HIV testing services: a systematic review and meta-analysis

Journal of the International AIDS Society
Cheryl C JohnsonRachel Baggaley

Abstract

HIV self-testing (HIVST) is a discreet and convenient way to reach people with HIV who do not know their status, including many who may not otherwise test. To inform World Health Organization (WHO) guidance, we assessed the effect of HIVST on uptake and frequency of testing, as well as identification of HIV-positive persons, linkage to care, social harm, and risk behaviour. We systematically searched for studies comparing HIVST to standard HIV testing until 1 June 2016. Meta-analyses of studies reporting comparable outcomes were conducted using a random-effects model for relative risks (RR) and 95% confidence intervals. The quality of evidence was evaluated using GRADE. After screening 638 citations, we identified five randomized controlled trials (RCTs) comparing HIVST to standard HIV testing services among 4,145 total participants from four countries. All offered free oral-fluid rapid tests for HIVST and were among men. Meta-analysis of three RCTs showed HIVST doubled uptake of testing among men (RR = 2.12; 95% CI: 1.51, 2.98). Meta-analysis of two RCTs among men who have sex with men showed frequency of testing nearly doubled (Rate ratio = 1.88; 95% CI: 1.17; 3.01), resulting in two more tests in a 12-15-month period (Mean d...Continue Reading

References

Aug 2, 2011·Journal of Clinical Epidemiology·Gordon H GuyattHolger J Schünemann
Aug 16, 2012·AIDS and Behavior·Alex Carballo-DiéguezCurtis Dolezal
Oct 12, 2012·PloS One·Luis de la FuenteUNKNOWN Madrid Rapid HIV Testing Group
Aug 9, 2013·BMC Public Health·Janne KrauseRobert Colebunders
Jul 6, 2014·AIDS and Behavior·Annette N BrownDrew B Cameron
May 30, 2015·The Medical Journal of Australia·Rebecca J GuyDavid P Wilson
Jun 10, 2015·AIDS and Behavior·Carmen FigueroaRachel Baggaley

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Citations

Apr 11, 2018·Expert Review of Anti-infective Therapy·Jason J OngJoseph D Tucker
Nov 22, 2017·PLoS Medicine·Michael M ChandaCatherine E Oldenburg
Apr 27, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·David A KatzJoanne D Stekler
May 31, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Katrina F OrtbladCatherine E Oldenburg
Feb 2, 2019·Current HIV/AIDS Reports·Sybil Hosek, Audrey Pettifor
Feb 15, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Anna L BowringStefan Baral
Mar 26, 2019·Journal of the International AIDS Society·Moses K KumwendaElizabeth L Corbett
Apr 3, 2019·BMJ : British Medical Journal·Carmen H LogieClaire Uwase Kipenda
Sep 29, 2019·International Journal of STD & AIDS·Paula BaraitserMichael Brady
Mar 10, 2020·Sexually Transmitted Diseases·Zoe R EdelsteinJulie E Myers
Mar 14, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jeffrey E KorteRhoda K Wanyenze
Jun 25, 2020·Journal of the International AIDS Society·Augustine T ChokoUNKNOWN World Health Organization HIV self-testing technical working group
Jul 7, 2020·International Journal of STD & AIDS·Zubairu IliyasuMuktar H Aliyu

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Software Mentioned

Skype
HIVST
REVMAN
OraQuick

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