Examining the feasibility of mixture risk assessment: A case study using a tiered approach with data of 67 pesticides from the Joint FAO/WHO Meeting on Pesticide Residues (JMPR)

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Richard M EvansAndreas Kortenkamp

Abstract

The way in which mixture risk assessment (MRA) should be included in chemical risk assessment is a current topic of debate. We used data from 67 recent pesticide evaluations to build a case study using Hazard Index calculations to form risk estimates in a tiered MRA approach in line with a Framework proposed by WHO/IPCS. The case study is used to illustrate the approach and to add detail to the existing Framework, and includes many more chemicals than previous case studies. A low-tier MRA identified risk as being greater than acceptable, but refining risk estimates in higher tiers was not possible due to data requirements not being readily met. Our analysis identifies data requirements, which typically expand dramatically in higher tiers, as being the likely cause for an MRA to fail in many realistic cases. This forms a major obstacle to routine implementation of MRA and shows the need for systematic generation and collection of toxicological data. In low tiers, hazard quotient inspection identifies chemicals that contribute most to the HI value and thus require attention if further refinement is needed. Implementing MRA requires consensus on issues such as scope setting, criteria for performing refinement, and decision criteri...Continue Reading

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Citations

Nov 6, 2015·Journal of Toxicologic Pathology·Midori YoshidaMiwa Takahashi
May 24, 2015·Regulatory Toxicology and Pharmacology : RTP·Jürg A ZarnBarbara E Engeli
Sep 17, 2015·Pest Management Science·Michael HoubrakenPieter Spanoghe
May 18, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Davide FerrigoRoberto Causin
Aug 16, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Zhixia LiZhen Yan
Sep 28, 2017·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Miguel A CamaraJose Oliva
Apr 2, 2019·Critical Reviews in Toxicology·Stephanie K BoppAndrew P Worth
Aug 20, 2019·Journal of Food Protection·Paloma QuintanillaM Pilar Molina
Mar 20, 2019·Environmental Science and Pollution Research International·Senar AydinArzu Ulvi
Jul 28, 2016·Environmental Monitoring and Assessment·Lara NasreddineFarouk Jaber
Aug 24, 2017·Pest Management Science·Matteo AnaclerioLuigi Lucini
Jul 3, 2020·Physical Chemistry Chemical Physics : PCCP·Jasvir Kaur, Prabhat K Singh
Jan 12, 2019·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Jin GongDeyu Hu
Feb 8, 2019·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Ling R ZengDe Y Hu
Feb 19, 2019·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Ting GuiDe Y Hu
May 21, 2020·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Qinghua YaoQiu Lin
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Mar 7, 2021·Journal of Environmental Management·Diego ValbuenaDiana Obregón

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