Examining the gastrointestinal transit of lipid-based liquid crystalline systems using whole-animal imaging

Drug Delivery and Translational Research
Anna C PhamBen J Boyd

Abstract

Lipid-based liquid crystalline (LC) systems have the potential to sustain the oral absorption of poorly water-soluble drugs in vivo, facilitating slow drug release from their complex internal structure. To further evaluate the dynamic relationship between gastric retention and sustained drug absorption for these systems, this study aimed to explore non-invasive X-ray micro-CT imaging as an approach to assess gastric retention. Pharmacokinetic studies were also conducted with cinnarizine-loaded LC formulations to correlate gastric retention of the formulation to drug absorption. The in vivo studies demonstrated the interplay between gastric retention and drug absorption based on the digestibility of the LC structures. An increase in non-digestible phytantriol (PHY) composition in the formulation relative to digestible glyceryl monooleate (GMO) increased the gastric retention, with 68 ± 4 % of formulation intensity remaining at 8 h for 85 % w/w PHY, and 26 ± 9 % for 60 % w/w PHY. Interestingly, it was found that PHY 30 % w/w in GMO provided the highest bioavailability for cinnarizine (CZ) amongst the other combinations, including GMO alone. The studies demonstrated that combining digestible and non-digestible lipids into LC syste...Continue Reading

References

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Apr 19, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tri-Hung NguyenBen J Boyd
Sep 14, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Wye-Khay FongBen J Boyd
May 9, 2015·Physical Chemistry Chemical Physics : PCCP·Joanne D DuBen J Boyd

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Citations

Mar 31, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J E DalzielN C Roy
Sep 14, 2016·Journal of Colloid and Interface Science·Wye-Khay FongBen J Boyd

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