Examining the identification of age-related atrophy between T1 and T1 + T2-FLAIR cortical thickness measurements

Scientific Reports
Heidi LindrothRobert D Sanders

Abstract

Cortical thickness is traditionally derived from T1-weighted MRI images. Recent studies have shown an improvement in segmentation with the combination of T1 + T2-FLAIR images. MRI data from 54 adults (mean: 71 years, 65-81 years, 48% females) that are part of an ongoing cohort study were analyzed to investigate whether T1 + T2-FLAIR cortical thickness measurements were superior to those derived from T1-weighted images in identifying age-related atrophy. T1-weighted and T2-FLAIR MRI images were processed through FreeSurfer v6.0. Data was extracted using the Desikan-Killiany (DKT) atlas. FreeSurfer's GUI QDEC examined age-related atrophy. Nonparametric tests, effect sizes, and Pearson correlations examined differences between T1-only and T1 + T2-FLAIR cortical thickness data. These analyses demonstrated that T1 + T2-FLAIR processed images significantly improved the segmentation of gray matter (chi-square x2, p < 0.05) and demonstrated significantly thicker cortical thickness means (p < 0.05) with medium to large effect sizes. Significant regions of age-related cortical atrophy were identified within the T1 + T2-FLAIR data (FDR corrected, p < 0.05). This is in contrast to the T1-only data where no regions survived FDR correction. ...Continue Reading

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Citations

Jul 21, 2020·Human Brain Mapping·Baptiste Couvy-DuchesnePeter M Visscher

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Clinical Trials Mentioned

NCT03124303
NCT01980511

Software Mentioned

ComBat
recon
FreeSurfer Query , Design , Estimate , Contrast ( QDEC )
FreeSurfer
GUI QDEC
ComBat Harmonization
all

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