Examining the independent and joint effects of genomic and exposomic liabilities for schizophrenia across the psychosis spectrum.

Epidemiology and Psychiatric Sciences
L-K PriesS Guloksuz

Abstract

Psychosis spectrum disorder has a complex pathoetiology characterised by interacting environmental and genetic vulnerabilities. The present study aims to investigate the role of gene-environment interaction using aggregate scores of genetic (polygenic risk score for schizophrenia (PRS-SCZ)) and environment liability for schizophrenia (exposome score for schizophrenia (ES-SCZ)) across the psychosis continuum. The sample consisted of 1699 patients, 1753 unaffected siblings, and 1542 healthy comparison participants. The Structured Interview for Schizotypy-Revised (SIS-R) was administered to analyse scores of total, positive, and negative schizotypy in siblings and healthy comparison participants. The PRS-SCZ was trained using the Psychiatric Genomics Consortiums results and the ES-SCZ was calculated guided by the approach validated in a previous report in the current data set. Regression models were applied to test the independent and joint effects of PRS-SCZ and ES-SCZ (adjusted for age, sex, and ancestry using 10 principal components). Both genetic and environmental vulnerability were associated with case-control status. Furthermore, there was evidence for additive interaction between binary modes of PRS-SCZ and ES-SCZ (above 75...Continue Reading

References

May 1, 1976·American Journal of Epidemiology·K J Rothman
Jun 1, 1990·Archives of General Psychiatry·J K WingN Sartorius
Jan 1, 1989·Schizophrenia Bulletin·K S KendlerD Walsh
Oct 1, 1980·American Journal of Epidemiology·K J RothmanA M Walker
Sep 19, 2000·Schizophrenia Bulletin·M G Vollema, J Ormel
Mar 5, 2003·Child Abuse & Neglect·David P BernsteinWilliam Zule
May 14, 2004·The Spanish Journal of Psychology·Simon C HunterRosario Ortega
Aug 30, 2007·International Journal of Epidemiology·Mirjam J KnolMirjam I Geerlings
Jul 9, 2008·American Journal of Human Genetics·Alkes L PriceDavid Reich
Feb 13, 2009·American Journal of Epidemiology·David B Richardson, Jay S Kaufman
Sep 3, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Kenneth S Kendler, Charles O Gardner
Jul 22, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ruud van WinkelUNKNOWN Genetic Risk and Outcome of Psychosis (GROUP) Investigators
Jan 19, 2012·International Journal of Epidemiology·Mirjam J Knol, Tyler J VanderWeele
Oct 18, 2013·Frontiers in Psychiatry·Pierre Alexis GeoffroyJosselin Houenou
Jul 25, 2014·Nature·UNKNOWN Schizophrenia Working Group of the Psychiatric Genomics Consortium
Jan 9, 2016·Neuroscience and Biobehavioral Reviews·Mascha M J LinszenIris E Sommer
Aug 30, 2016·Nature Genetics·Sayantan DasChristian Fuchsberger
Oct 28, 2016·Nature Genetics·Po-Ru LohAlkes L Price
Feb 10, 2017·Schizophrenia Research·Miguel BernardoUNKNOWN PEPs GROUP
Jul 12, 2017·Molecular Psychiatry·L Colodro-CondeN G Martin
Oct 6, 2017·American Journal of Epidemiology·Beate R RitzKimberly McAllister
Jan 21, 2018·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Joaquim RaduaPaolo Fusar-Poli
May 29, 2018·Biological Psychiatry·Holger J SørensenLiselotte Petersen
Sep 1, 2018·Schizophrenia Bulletin·Sinan GuloksuzUNKNOWN European Network of National Schizophrenia Networks Studying Gene-Environment Interactions Work Package 6 (EU-GEI WP6) Group
Jan 20, 2019·Translational Psychiatry·Aleix Arnau-SolerPippa A Thomson
May 7, 2019·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Sinan GuloksuzJim van Os

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Citations

Nov 21, 2020·Schizophrenia Bulletin·Lotta-Katrin PriesSinan Guloksuz
Mar 20, 2021·European Psychiatry : the Journal of the Association of European Psychiatrists·Gamze ErzinSinan Guloksuz
Jun 15, 2021·Frontiers in Psychiatry·Lotta-Katrin PriesSinan Guloksuz
Nov 26, 2021·The British Journal of Clinical Psychology·Emiliana ToniniMelissa J Green

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Methods Mentioned

BETA
genotyping
chips

Software Mentioned

Stata
PLINK
GenomeStudio
Eagle
EUGEI
Minimac3
custom Perl scripts

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