Examining the relationship between blast-induced mild traumatic brain injury and posttraumatic stress-related traits

Journal of Neuroscience Research
A E TschiffelyJ N Norris

Abstract

Emerging evidence suggests that mild traumatic brain injury (mTBI) resulting from blast exposure may contribute to the occurrence of posttraumatic stress disorder (PTSD) and related affective sequelae, such as anxiety and depression. Many studies have used survey techniques to describe blast exposure leading to comorbid mTBI and related persistent postconcussive symptoms (PPCS) with PTSD in military populations. Despite this, there is a lack of literature that examines possible biological mechanisms by which blast exposure contributes to the development of PTSD sequelae. This Mini-Review addresses the current literature on potential neurophysiological changes that may contribute to PTSD-like traits as a result of a single or multiple exposures to blast events. Evidence from clinical blast-induced mTBI populations and animal models of blast-induced mTBI was evaluated with an emphasis on behavioral and physiological symptoms similar to those seen in PTSD populations and models. From the analysis, we propose potential mechanisms that merit further investigation for better understanding of how blast exposures may produce a higher rate of comorbid PPCS, PTSD, and affective phenomena. An improved understanding of PTSD-like outcomes r...Continue Reading

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Citations

Jul 30, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mihai PopescuThomas J DeGraba
Oct 10, 2019·Journal of Neurotrauma·Peethambaran ArunJoseph B Long
Feb 6, 2017·Journal of Neuroscience Research·Laura S Moye, Amynah A Pradhan

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