Examining the time course of endothelium-independent dilation by nitroglycerin

Ultrasound in Medicine & Biology
Andrea M ThelenDonald R Dengel

Abstract

Arterial smooth muscle function is commonly assessed by measuring the dilation response to sublingual nitroglycerin (NTG), and is referred to as endothelium-independent dilation (EID). The time point at which the brachial artery dilates maximally after NTG administration is generally believed to occur somewhere between three and five minutes. The aim of this study was to examine the time course of brachial artery dilation response to a single dose of sublingual NTG to identify the time point at which maximal dilation occurs and to assess factors effecting EID. Endothelial independent dilation was measured in 125 normal, healthy subjects (male = 67, female = 58) via high-resolution ultrasound on the brachial artery. Mean time to maximal EID was 279.0 +/- 26.9 s. There was a significant (p < 0.0001) difference between brachial EID at three minutes vs. five minutes post NTG. There was also a significant gender difference in EID response (p < 0.0001). The results of this study indicate that maximal EID occurs approximately five minutes after NTG administration. Measuring EID at three minutes after NTG administration likely underestimates the true dilation capacity of the artery.

References

Nov 15, 2000·The American Journal of Cardiology·B BresslerG B Mancini
Jan 15, 2002·Journal of the American College of Cardiology·Mary C CorrettiUNKNOWN International Brachial Artery Reactivity Task Force
Aug 28, 2004·Journal of Magnetic Resonance Imaging : JMRI·Alessia PepeEugenio Picano
Dec 14, 2004·Ultrasound in Medicine & Biology·Aaron S KellyAlan J Bank

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Citations

Nov 29, 2008·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Tyler A BoschDonald R Dengel
Dec 23, 2015·Journal of Clinical Ultrasound : JCU·Nicholas G EvanoffDonald R Dengel
Feb 3, 2012·Clinical Physiology and Functional Imaging·Meghan C McCueDonald R Dengel
Jul 21, 2011·Clinical Physiology and Functional Imaging·Kara L MarlattDonald R Dengel
Mar 8, 2018·Physiological Measurement·Michelle M HarbinDonald R Dengel
Jun 19, 2019·European Heart Journal·Dick H J ThijssenLorenzo Ghiadoni
Aug 26, 2015·American Journal of Lifestyle Medicine·Donald R Dengel, Justin R Ryder

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