Examining Treatment Outcomes with Erlotinib in Patients with Advanced Non-Small Cell Lung Cancer Whose Tumors Harbor Uncommon EGFR Mutations

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Barbara KlughammerDavid S Shames

Abstract

Exon 19 deletions and the exon 21 L858R mutation of the epidermal growth factor receptor gene (EGFR) predict activity of EGFR tyrosine kinase inhibitors, including erlotinib; however, the ability of less common EGFR mutations to predict efficacy of erlotinib is unclear. The efficacy of erlotinib in individual patients with rare EGFR mutations from the MERIT, SATURN, TITAN, TRUST, ATLAS, BeTa, and FASTACT-2 trials was analyzed and compared with data from the literature. In the patients tested for biomarkers, the frequency of rare mutations identified here ranged from 1.7% (eight of 467) in the SATURN study to 7.4% (27 of 364) in ATLAS. Some rare mutations were associated with greater clinical benefit from EGFR tyrosine kinase inhibitor therapy or improved prognosis independent of treatment, whereas others appeared to have a poorer prognosis. In particular, exon 18 G719 mutations, exon 19 K757R and E746G mutations, the exon 20 S768I mutation, and the exon 21 G836S mutation appeared to confer a good outcome with erlotinib treatment, whereas exon 18 S720I showed a particularly poor outcome. Owing to the small number of patients with each mutation, however, it is difficult to confirm whether these rare mutations do indeed confer sen...Continue Reading

References

Feb 16, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sae-Won HanNoe Kyeong Kim
May 18, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Teh-Ying ChouChun-Ming Tsai
Jul 15, 2005·The New England Journal of Medicine·Frances A ShepherdUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Dec 6, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Claus-Peter SchneiderMartin Reck
Jan 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rama Krishna KanchaJustus Duyster
Aug 26, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Martin ReckDavid Heigener
May 3, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jenn-Yu WuPan-Chyr Yang
Aug 16, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Tommaso De PasMassimo Barberis
Oct 5, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wolfram BruggerFederico Cappuzzo
Jan 31, 2012·The Lancet Oncology·Rafael RosellUNKNOWN Spanish Lung Cancer Group in collaboration with Groupe Français de Pneumo-Cancérologie and Associazione Italiana Oncologia T
Aug 17, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Marius Lund-IversenOdd Terje Brustugun
Jan 19, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Geoffrey R OxnardPasi A Jänne
Jan 25, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paul YehLeora Horn
Mar 15, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Erminia MassarelliVassiliki Papadimitrakopoulou
Jan 7, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Anthony W H ChanKa Fai To
Jan 15, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Satoshi WatanabeKunihiko Kobayashi
Feb 27, 2014·The Journal of Clinical Investigation·Marcin ImielinskiDavid P Carbone
Dec 17, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jin Ho BaekKeunchil Park
Dec 19, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Lalit PallanPek Koh
Jan 7, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Oscar ArrietaUNKNOWN CLICaP
Feb 11, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Chao-Hua ChiuJames Chih-Hsin Yang
May 12, 2015·OncoTargets and Therapy·Liang PengShunchang Jiao

❮ Previous
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Citations

Jun 28, 2016·Expert Review of Molecular Diagnostics·Yuan TangWeiping Liu
Oct 27, 2017·Nature Reviews. Cancer·Julia Rotow, Trever G Bivona
Dec 23, 2017·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Hua-Li LiuQi-Bin Song
Oct 13, 2018·Asia-Pacific Journal of Clinical Oncology·Shengyu ZhouYuankai Shi
Jun 9, 2020·Briefings in Bioinformatics·Pora KimZhongming Zhao
May 9, 2019·International Journal of Clinical Oncology·Xiaohong LiangChong Li
Apr 3, 2020·Expert Review of Respiratory Medicine·Simona Scodes, Federico Cappuzzo
Aug 14, 2019·Pathology Oncology Research : POR·Hussein NassereddineAurélie Cazes
Nov 16, 2016·ESMO Open·Teresa TroianiFortunato Ciardiello
Jan 17, 2020·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Eva Boysen Fynboe EbertPeter Meldgaard
Jan 14, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·James Chih-Hsin YangEdward S Kim
Nov 28, 2017·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hai-Yan TuYi-Long Wu
Apr 29, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Lei Deng, Haiying Cheng
Sep 17, 2021·Nature·Jacqulyne P RobichauxJohn V Heymach

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