Examining Whether AOSLO-Based Foveal Cone Metrics in Achromatopsia and Albinism Are Representative of Foveal Cone Structure.

Translational Vision Science & Technology
Katie M LittsJoseph Carroll

Abstract

Adaptive optics scanning light ophthalmoscopy (AOSLO) imaging in patients with achromatopsia (ACHM) and albinism is not always successful. Here, we tested whether optical coherence tomography (OCT) measures of foveal structure differed between patients for whom AOSLO images were either quantifiable or unquantifiable. The study included 166 subjects (84 with ACHM; 82 with albinism) with previously acquired OCT scans, AOSLO images, and best-corrected visual acuity (BCVA, if available). Foveal OCT scans were assessed for outer retinal structure, outer nuclear layer thickness, and hypoplasia. AOSLO images were graded as quantifiable if a peak cone density could be measured and/or usable if the location of peak density could be identified and the parafoveal mosaic was quantifiable. Forty-nine percent of subjects with ACHM and 57% of subjects with albinism had quantifiable AOSLO images. Older age and better BCVA were found in subjects with quantifiable AOSLO images for both ACHM (P = 0.0214 and P = 0.0276, respectively) and albinism (P = 0.0073 and P < 0.0004, respectively). There was a significant trend between ellipsoid zone appearance and ability to quantify AOSLO (P = 0.0028). In albinism, OCT metrics of cone structure did not di...Continue Reading

References

Jan 23, 2004·The British Journal of Ophthalmology·M MichaelidesA T Moore
Feb 13, 2008·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·P ThévenazM Unser
Jun 25, 2010·Investigative Ophthalmology & Visual Science·Alberta A H J ThiadensCaroline C W Klaver
Jun 24, 2011·Biomedical Optics Express·Alfredo Dubra, Yusufu Sulai
Jul 14, 2012·The British Journal of Ophthalmology·Mervyn George ThomasIrene Gottlob
Aug 30, 2012·Nature Methods·Caroline A SchneiderKevin W Eliceiri
Sep 10, 2013·Middle East African Journal of Ophthalmology·Richard W Hertle
Sep 21, 2013·Translational Vision Science & Technology·Andrea L VincentFulton Wong
Oct 24, 2013·Ophthalmology·Venki SundaramMichel Michaelides
May 23, 2014·Investigative Ophthalmology & Visual Science·Melissa A WilkJoseph Carroll
Jun 8, 2014·Investigative Ophthalmology & Visual Science·Drew ScolesAlfredo Dubra
Aug 12, 2014·Investigative Ophthalmology & Visual Science·Jonathan AboshihaMichel Michaelides
Oct 4, 2014·Investigative Ophthalmology & Visual Science·Adam M DubisMichel Michaelides
Jul 24, 2015·Biomedical Optics Express·Christy K SheehyAustin Roorda
Aug 26, 2015·Ophthalmic Research·Ditta ZoborSusanne Kohl
Mar 5, 2016·Translational Vision Science & Technology·Robert F CooperJoseph Carroll
Aug 2, 2016·Investigative Ophthalmology & Visual Science·Christopher S LangloUNKNOWN ACHM-001 Study Group
Nov 27, 2016·Vision Research·Melissa A WilkJoseph Carroll
Feb 2, 2017·Retina·Christopher S LangloUNKNOWN ACHM-001 study group
Feb 6, 2017·Investigative Ophthalmology & Visual Science·Ditta ZoborUNKNOWN RD-CURE Consortium
Jan 6, 2018·Ophthalmic Genetics·Nashila HirjiMichel Michaelides
Jun 27, 2019·Investigative Ophthalmology & Visual Science·Rebecca R MasteyJoseph Carroll
Oct 12, 2019·Translational Vision Science & Technology·Rebecca R MasteyJoseph Carroll
Dec 12, 2019·Investigative Ophthalmology & Visual Science·Michalis GeorgiouMichel Michaelides
Feb 29, 2020·Current Eye Research·Katie M LittsJoseph Carroll
Mar 21, 2020·Investigative Ophthalmology & Visual Science·Erica N WoertzJoseph Carroll
Mar 24, 2020·Investigative Ophthalmology & Visual Science·Michalis GeorgiouMichel Michaelides
Jun 17, 2020·Journal of Vision·Erica N WoertzEdgar A DeYoe
Sep 1, 2020·Investigative Ophthalmology & Visual Science·Rachel E LindermanJoseph Carroll
Dec 18, 2020·Investigative Ophthalmology & Visual Science·Jenna A CavaJoseph Carroll

❮ Previous
Next ❯

Software Mentioned

GraphPad
ImageJ
OCT Reflectivity Analytics ( ORA )
Lattice
MATLAB
TurboReg
ORA
Prism
AOSLO

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.