Excellent outcome of allogeneic hematopoietic stem cell transplantation using a conditioning regimen with medium-dose VP-16, cyclophosphamide and total-body irradiation for adult patients with acute lymphoblastic leukemia

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Akio ShigematsuMasahiro Imamura

Abstract

We retrospectively evaluated the outcomes of 37 adult patients with acute lymphoblastic leukemia (ALL) undergoing allogeneic hematopoietic stem cell transplantation (allo-SCT) conditioned with medium-dose VP-16 (VP, 30 mg/kg), cyclophosphamide (CY, 120 mg/kg), and fractionated total-body irradiation (TBI, 12 Gy) (medium-dose VP/CY/TBI). The median age of the patients was 26 years. Thirteen patients underwent transplantation from HLA-matched related donors (MRD), 18 patients underwent transplantation from HLA-matched unrelated donors (MUD), and 6 patients underwent transplantation from HLA-mismatched donors (MMD). Thirty-two patients received bone marrow and 4 patients received peripheral blood stem cells. Ten patients were Philadelphia chromosome-positive (Ph(+)) and 35 patients were in complete remission (CR) at transplantation. All of the patients achieved engraftment, and grade 3 organ toxicity before engraftment occurred in 27 patients. Grade II-III acute graft-versus-host disease (GVHD) and chronic GVHD (cGVHD) occurred in 15 and 18 patients, respectively. No patient developed grade IV acute GVHD (aGVHD) or died of GVHD. At median follow-up of 35.1 months, 32 patients were alive and all Ph(+) patients were alive. Three pat...Continue Reading

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Citations

Oct 12, 2012·Cancer Chemotherapy and Pharmacology·Oystein BruserudKimberley Joanne Hatfield
Feb 18, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Haruhiko KashiwazakiNobuo Inoue
Apr 16, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Haruhiko KashiwazakiNobuo Inoue
Aug 27, 2010·Transplant Infectious Disease : an Official Journal of the Transplantation Society·A ShigematsuM Imamura
Dec 2, 2009·The Korean Journal of Internal Medicine·Masahiro Imamura, Junji Tanaka
Jul 14, 2012·Biological & Pharmaceutical Bulletin·Yuki TazawaMitsuru Sugawara
Aug 2, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Denise M OlianskyTheresa Hahn
May 20, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Akio ShigematsuMasahiro Imamura
Oct 4, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jun FangLinghui Xia
Feb 22, 2016·Seminars in Nuclear Medicine·Caroline Bodet-MilinPatrice Chevallier

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