Excellent renal function and reversal of nephrocalcinosis 8 years after isolated liver transplantation in an infant with primary hyperoxaluria type 1.

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Mónica Galanti, Angélica Contreras

Abstract

Primary hyperoxaluria type 1 (PH-1) is a rare autosomal recessive disease caused by the absence or deficiency of the liver-specific intermediary metabolic enzyme alanine glyoxylate aminotransferase. The prognosis of this metabolic disease is poor. Theoretically, the primary metabolic defect can be cured by liver transplantation. However, controversy exists around the age and stage of the disease that liver transplantation should be performed. We report on a patient who presented at the early age of 2 months with nephrocalcinosis. Isolated liver transplantation was performed at the age of 21 months. Eight years later, the estimated glomerular filtration rate was 85 ml/min/1.73 m(2), and imaging studies did not reveal nephrocalcinosis. This case report supports the strategy of early isolated liver transplantation in patients with PH-1.

References

Dec 8, 1994·The New England Journal of Medicine·D S MillinerL H Smith
Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E LeumannN Blau
Oct 27, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E Leumann, B Hoppe
Aug 10, 2000·Pediatric Transplantation·D NolkemperD E Müller-Wiefel
Feb 7, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S R EllisD A Kelly
Jan 17, 2002·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M F GagnadouxM Broyer
Aug 20, 2002·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sally A JohnsonSally-Anne Hulton
Dec 8, 2004·Retina·Wuqaas M MunirDebra A Goldstein
Jun 18, 2005·American Journal of Nephrology·Neville V Jamieson, UNKNOWN European PHI Transplantation Study Group
Jul 1, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Pierre CochatMarie-Odile Rolland
Aug 19, 2006·Pathology·Joon Joon KhooDyg Pertiwi Abg Kamaludin
Oct 6, 2006·Expert Opinion on Pharmacotherapy·Amy E Bobrowski, Craig B Langman
Feb 20, 2009·Kidney International·Bernd HoppeDawn S Milliner

❮ Previous
Next ❯

Citations

Aug 6, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jon I Scheinman
May 7, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hannu Jalanko, Mikko Pakarinen
Apr 13, 2013·Journal of Hepatology·Stefano FagiuoliGiuseppe Remuzzi
Apr 12, 2016·Pediatric Transplantation·Shirin Elizabeth KhorsandiNigel Heaton
Mar 14, 2020·Clinical Journal of the American Society of Nephrology : CJASN·Dawn S MillinerJohn C Lieske
Apr 1, 2021·The New England Journal of Medicine·Sander F GarrelfsUNKNOWN ILLUMINATE-A Collaborators
May 13, 2011·Current Opinion in Organ Transplantation

❮ Previous
Next ❯

Related Concepts

Related Feeds

Absence Epilepsy

Absence epilepsy is a common seizure disorder in children which can produce chronic psychosocial sequelae. Discover the latest research on absence epilepsies here.

Related Papers

Current Opinion in Organ Transplantation
Pierre CochatJérôme Harambat
Seminars in Nephrology
Amy E Bobrowski, Craig B Langman
Transplant International : Official Journal of the European Society for Organ Transplantation
Miguel BispoEduardo Barroso
The New England Journal of Medicine
Marina Noris, Giuseppe Remuzzi
© 2021 Meta ULC. All rights reserved