Exceptionally high payload of doxorubicin in hollow gold nanospheres for near-infrared light-triggered drug release.

ACS Nano
Jian YouChun Li

Abstract

We report dual-functional hollow gold nanospheres (HAuNS, approximately 40-nm diameter) capable of mediating both photothermal ablation of cancer cells and drug release upon near-infrared (NIR) light irradiation. As high as 63% DOX by weight ( approximately 1.7 microg DOX/microg Au) could be loaded to polyethylene glycol (PEG)-coated HAuNS since DOX was coated to both the outer and the inner surfaces of HAuNS. Irradiation with NIR laser induced photothermal conversion, which triggered rapid DOX release from DOX-loaded HAuNS. The release of DOX was also pH-dependent, with more DOX released in aqueous solution at lower pH. Significantly greater cell killing was observed when MDA-MB-231 cells incubated with DOX-loaded HAuNS were irradiated with NIR light, attributable to both HAuNS-mediated photothermal ablation and cytotoxicity of released free DOX.

References

Mar 29, 2000·Accounts of Chemical Research·A C TempletonR W Murray
May 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Chunhai FanAlan J Heeger
Mar 26, 2004·Nature Reviews. Molecular Cell Biology·Frederick R Maxfield, Timothy E McGraw
Apr 28, 2004·Advanced Drug Delivery Reviews·S S Davis
Apr 14, 2005·Chemical Reviews·Nathaniel L Rosi, Chad A Mirkin
Jun 7, 2005·Molecular Pharmaceutics·Tapan K JainVinod Labhasetwar
Jul 21, 2005·Molecular Pharmaceutics·Tatsuya MurakamiKiyotaka Shiba
Dec 6, 2005·Molecular Pharmaceutics·Kumiko AjimaSumio Iijima
Jan 19, 2006·Current Opinion in Chemical Biology·Mark Ming-Cheng ChengMauro Ferrari
May 2, 2006·Molecular Cancer Therapeutics·Rachana K VisariaJohn C Bischof
Jul 4, 2006·Pharmacology & Therapeutics·Nobuhiro Nishiyama, Kazunori Kataoka
Oct 6, 2006·The Journal of Physical Chemistry. B·Adam M SchwartzbergJin Z Zhang
Jun 16, 2007·Journal of the American Chemical Society·Rodney P FeazellStephen J Lippard
Aug 28, 2007·Journal of the American Chemical Society·Jacob D GibsonEugene R Zubarev
Dec 25, 2007·Analytical and Bioanalytical Chemistry·Pedro BaptistaRicardo Franco
Apr 1, 2008·Advanced Drug Delivery Reviews·Chun Li, Sidney Wallace
May 27, 2008·Advanced Drug Delivery Reviews·Resham Bhattacharya, Priyabrata Mukherjee
Jul 23, 2008·Journal of the American Chemical Society·Yu ChengClemens Burda
Jul 26, 2008·Nature Nanotechnology·Dan PeerRobert Langer
Jul 30, 2008·Journal of the American Chemical Society·Shanta DharStephen J Lippard
Aug 15, 2008·Cancer Research·Zhuang LiuHongjie Dai
Oct 14, 2008·Chemistry : a European Journal·Sheetal DharB L V Prasad
Jan 13, 2009·Journal of the American Chemical Society·Chae Kyu KimVincent M Rotello
Feb 4, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wei LuChun Li
Apr 1, 2009·Nano Letters·Asmaa ElbakryMiriam Breunig
May 9, 2009·Nano Letters·Jae-Seung LeeDaniel G Anderson

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Citations

Apr 24, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Mei TianSanjay Gupta
Sep 21, 2013·Biomaterials·Jing ZhouFuyou Li
Apr 10, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·J GautierI Chourpa
Jun 4, 2013·ACS Applied Materials & Interfaces·Wentao WangYilin Wang
Aug 19, 2011·Accounts of Chemical Research·Marites P MelanconChun Li
Jan 27, 2012·Journal of Medicinal Chemistry·Bhupender S ChhikaraKeykavous Parang
Jan 31, 2013·Molecular Pharmaceutics·Aneta J MieszawskaDavid P Cormode
Aug 25, 2012·Nano Letters·Carl WadellChristoph Langhammer
Jul 19, 2012·ACS Nano·James Chen Yong KahKimberly Hamad-Schifferli
Sep 11, 2010·Chemical Communications : Chem Comm·Clara YagüeJesus Santamaria
Apr 5, 2014·Nature Communications·Kevin A CarterJonathan F Lovell
Mar 13, 2014·Biomaterials·Miao GuoHuabing Chen
Nov 8, 2011·Therapeutic Delivery·Brian E O'Neill, Natalya Rapoport
Nov 1, 2010·Therapeutic Delivery·Himanshu BhattacharjeeGeorge C Wood
Nov 16, 2013·Therapeutic Delivery·James B DelehantyIgor L Medintz
May 23, 2012·Advanced Drug Delivery Reviews·Leonid Vigderman, Eugene R Zubarev
Nov 26, 2013·Advanced Drug Delivery Reviews·Swati Biswas, Vladimir P Torchilin
Jun 22, 2014·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Nihal Saad ElbialyWafaa Mohamed Khalil
Oct 25, 2014·Nanomedicine·Jun ZhaoMarites P Melancon
Jan 14, 2016·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Punit KaurSunil Krishnan
Oct 16, 2014·Expert Review of Molecular Diagnostics·Rita M Cabral, Pedro V Baptista
Feb 25, 2014·Expert Opinion on Drug Delivery·Roberto Cao-Milán, Luis M Liz-Marzán
Feb 24, 2011·Expert Opinion on Medical Diagnostics·Jimmy L SuStanislav Y Emelianov
Feb 4, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Sanjeeb KalitaJibon Kotoky
Feb 26, 2013·Colloids and Surfaces. B, Biointerfaces·Moorthy GaneshkumarLonchin Suguna
Mar 6, 2012·Advanced Drug Delivery Reviews·Nadezda FominaAdah Almutairi

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