Exceptionally stable fluorous emulsions for the intravenous delivery of volatile general anesthetics.

Anesthesiology
Jun-Pil JeeRobert A Pearce

Abstract

IV delivery of volatile fluorinated anesthetics has a number of potential advantages when compared with the current inhalation method of administration. We reported previously that the IV delivery of sevoflurane can be achieved through an emulsion composed of a linear fluorinated diblock copolymer, a stabilizer, and the anesthetic. However, this original emulsion was subject to particle size growth that would limit its potential clinical utility. We hypothesized that the use of bulkier fluorous groups and smaller polyethylene glycol moieties in the polymer design would result in improved emulsion stability while maintaining anesthetic functionality. The authors prepared emulsions incorporating sevoflurane, perfluorooctyl bromide as a stabilizing agent, and combinations of linear fluorinated diblock copolymer and a novel dibranched fluorinated diblock copolymer. Emulsion stability was assessed using dynamic light scattering. The ability of the emulsions to induce anesthesia was tested in vivo by administering them intravenously to 15 male Sprague-Dawley rats and measuring loss of the forepaw righting reflex. 20% (volume/volume) sevoflurane emulsions incorporating mixtures of dibranched and linear diblock copolymers had improved ...Continue Reading

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Citations

Dec 12, 2012·Frontiers of Medicine·Cheng Zhou, Jin Liu
Jul 4, 2013·Current Opinion in Anaesthesiology·Tony Gin
Oct 10, 2015·Veterinary Anaesthesia and Analgesia·Claudio C NataliniAnthony Nicholson
Apr 23, 2016·Anesthesia and Analgesia·Timothy E Morey
Dec 3, 2014·Journal of Colloid and Interface Science·Ibrahim E SalamaAlison Paul
Jan 21, 2012·Anesthesiology·Evan D Kharasch
Mar 27, 2019·Expert Opinion on Drug Discovery·Bernd Antkowiak, Gerhard Rammes
Aug 1, 2016·Chemical Science·Ellen M Sletten, Timothy M Swager

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