PMID: 18716161Aug 22, 2008Paper

Excess dietary L-cysteine causes lethal metabolic acidosis in chicks

The Journal of Nutrition
R N Dilger, D H Baker

Abstract

A 72-h time-course study was conducted to elucidate the physiological mechanism underlying cysteine (Cys) toxicity in chicks beginning at 8-d posthatch. Biochemical markers quantified in plasma and liver samples collected from chicks receiving 30 g/kg excess dietary Cys were compared with baseline measurements from chicks receiving an unsupplemented corn-soybean meal diet over a 72-h feeding period. Concomitant with chick mortality were indices of acute metabolic acidosis, including a rapid increase (P < 0.001) in anion gap that resulted from a reduction (P < 0.001) in plasma HCO(3)(-) of approximately 40% and a 2.8-fold increase (P < 0.001) in plasma sulfate in chicks receiving excess Cys. Additionally, provision of 30 g/kg excess Cys resulted in a 1.5-fold increase (P < 0.05) in hepatic oxidized glutathione compared with the 0-h control time-point. Excess dietary Cys did not affect plasma free Met, but plasma free Cys increased (P < 0.05) from 89 to 107 mumol/L at 12 h and remained elevated through 36 h. Strikingly, ingestion of 30 g/kg excess Cys caused more than a doubling (P < 0.001) of plasma free cystine, the oxidized form of Cys, beginning 12 h after initiating the study, and it remained elevated throughout the 72-h fee...Continue Reading

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Citations

Jul 9, 2013·Bioscience, Biotechnology, and Biochemistry·Seulki LeeMichihiro Fukushima
Nov 15, 2008·Amino Acids·David H Baker
Feb 6, 2018·Annals of the New York Academy of Sciences·Zhen DongJohn P Richie
Apr 26, 2020·Animals : an Open Access Journal From MDPI·Peter H SelleSonia Y Liu
Jun 26, 2021·Pharmacology & Therapeutics·Brandán PedreTobias P Dick

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