Excess iron: considerations related to development and early growth

The American Journal of Clinical Nutrition
Marianne Wessling-Resnick

Abstract

What effects might arise from early life exposures to high iron? This review considers the specific effects of high iron on the brain, stem cells, and the process of erythropoiesis and identifies gaps in our knowledge of what molecular damage may be incurred by oxidative stress that is imparted by high iron status in early life. Specific areas to enhance research on this topic include the following: longitudinal behavioral studies of children to test associations between iron exposures and mood, emotion, cognition, and memory; animal studies to determine epigenetic changes that reprogram brain development and metabolic changes in early life that could be followed through the life course; and the establishment of human epigenetic markers of iron exposures and oxidative stress that could be monitored for early origins of adult chronic diseases. In addition, efforts to understand how iron exposure influences stem cell biology could be enhanced by establishing platforms to collect biological specimens, including umbilical cord blood and amniotic fluid, to be made available to the research community. At the molecular level, there is a need to better understand stress erythropoiesis and changes in iron metabolism during pregnancy and...Continue Reading

Citations

Feb 27, 2020·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Ya Hui HungAshley I Bush
Dec 19, 2020·International Journal of Molecular Sciences·Jacek BajHanna Karakula-Juchnowicz
Sep 23, 2021·The Proceedings of the Nutrition Society·Elaine K McCarthyMairead E Kiely
Dec 21, 2021·Nutritional Neuroscience·Patricia L EastSheila Gahagan

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