Excess mortality due to depression and anxiety in the United States: results from a nationally representative survey

General Hospital Psychiatry
Laura A PrattElizabeth Reisinger Walker

Abstract

We compared the mortality of persons with and without anxiety and depression in a nationally representative survey and examined the role of socioeconomic factors, chronic diseases and health behaviors in explaining excess mortality. The 1999 National Health Interview Survey was linked with mortality data through 2011. We calculated the hazard ratio (HR) for mortality by presence or absence of anxiety/depression and evaluated potential mediators. We calculated the population attributable risk of mortality for anxiety/depression. Persons with anxiety/depression died 7.9 years earlier than other persons. At a population level, 3.5% of deaths were attributable to anxiety/depression. Adjusting for demographic factors, anxiety/depression was associated with an elevated risk of mortality [HR=1.61, 95% confidence interval (CI)=1.40, 1.84]. Chronic diseases and health behaviors explained much of the elevated risk. Adjusting for demographic factors, people with past-year contact with a mental health professional did not demonstrate excess mortality associated with anxiety/depression while those without contact did. Anxiety/depression presents a mortality burden at both individual and population levels. Our findings are consistent with ta...Continue Reading

Citations

May 17, 2017·Global Qualitative Nursing Research·Noriko Yamamoto-MitaniHiroki Fukahori
Nov 15, 2018·Hormone Molecular Biology and Clinical Investigation·Kai G Kahl
Jan 24, 2019·JAMA Psychiatry·Karmel W ChoiUNKNOWN Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Aug 23, 2019·Journal of Neurology·Huan CaiJialin Liang
May 19, 2016·The Journal of ECT·William M McDonaldW Vaughn McCall
Jun 17, 2020·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Zeynep NasFrühling V Rijsdijk
Aug 30, 2018·Current Psychiatry Reports·Elizabeth Reisinger Walker, Benjamin G Druss
Nov 2, 2019·Journal of General Internal Medicine·Ranak B TrivediCharles Maynard
Aug 15, 2020·Epidemiology and Psychiatric Sciences·Yi-Ju PanChin-Kuo Chang
Nov 13, 2016·European Psychiatry : the Journal of the Association of European Psychiatrists·M HallgrenY Forsell
Oct 24, 2020·Journal of Psychosocial Nursing and Mental Health Services·Patricia B NemecCrystal L Brandow
Jan 8, 2021·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Hyunjung Lee, Gopal K Singh
Jan 28, 2021·Psychiatric Services : a Journal of the American Psychiatric Association·Benjamin R SzymanskiIra R Katz
Oct 24, 2017·American Journal of Preventive Medicine·Bobbi Jo H YarboroughCarla A Green
Sep 6, 2020·Developmental Cognitive Neuroscience·Lyndsey Juliane ChongAlexandria Meyer
Mar 30, 2021·Bulletin of the Menninger Clinic·Samantha G Farris, Ana M Abrantes
Apr 30, 2021·Therapeutic Advances in Psychopharmacology·Philip BrennerTherese M-L Andersson
May 4, 2021·Current Opinion in Anaesthesiology·David B Guthrie, Deborah C Richman
May 6, 2021·Journal of the International Neuropsychological Society : JINS·Garrett A ThomasPeter A Arnett
Jun 9, 2021·Social Psychiatry and Psychiatric Epidemiology·Katharine B ParodiZiming Xuan
Jun 6, 2021·Journal of Pharmaceutical Sciences·Akeemat O TijaniAshana Puri
Aug 10, 2021·Computational Intelligence and Neuroscience·Sumaiya Tarannum NoorMehedi Masud
Aug 29, 2021·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Qi WuSteve Parrott
Nov 25, 2021·Suicide & Life-threatening Behavior·Tyler C HeinJohn F McCarthy

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