Excess mortality related to circulatory system diseases and diabetes mellitus among Italian AIDS patients vs. non-AIDS population: a population-based cohort study using the multiple causes-of-death approach

BMC Infectious Diseases
Barbara SuligoiAntonella Zucchetto

Abstract

Chronic diseases, chiefly cancers and circulatory system diseases (CSDs), have become the leading non-AIDS-related causes of death among HIV-infected people, as in the general population. After our previous report of an excess mortality for several non-AIDS-defining cancers, we now aim to assess whether people with AIDS (PWA) experience also an increased mortality for CSDs and diabetes mellitus (DM), as compared to the non-AIDS general population (non-PWA). A nationwide, population-based, retrospective cohort study was conducted including 5285 Italians, aged 15-74 years, who were diagnosed with AIDS between 2006 and 2011. Multiple cause-of-death (MCoD) data, i.e. all conditions reported in death certificates, were retrieved through record-linkage with the National Register of Causes of Death up to 2011. Using MCoD data, sex- and age-standardized mortality ratios (SMRs) with 95% confidence intervals (CIs) were calculated by dividing the observed number of PWA reporting a specific disease among MCoD to the expected number, estimated on the basis of mortality rates (based on MCoD) of non-PWA. Among 1229 deceased PWA, CSDs were mentioned in 201 (16.4%) certificates and DM in 46 (3.7%) certificates among the various causes of death....Continue Reading

References

Feb 13, 1993·Lancet·R Ancelle-Park
Aug 30, 2002·Journal of Biomedical Informatics·L Dal MasoS Franceschi
Jul 12, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marianne SavèsUNKNOWN French WHO MONICA Project and the APROCO (ANRS EP11) Study Group
May 23, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Niels ObelJan Gerstoft
Sep 21, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert C KaplanStephen J Gange
Apr 13, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·UNKNOWN Antiretroviral Therapy Cohort Collaboration
May 26, 2010·AIDS Research and Therapy·Diego SerrainoGiovanni Rezza
Mar 1, 2013·Current Diabetes Reports·Sanjay Kalra, Navneet Agrawal
Nov 12, 2013·Neurology·Farrah J MateenUNKNOWN Multicenter AIDS Cohort Study (MACS) Investigators
Oct 3, 2014·AIDS Patient Care and STDs·Sandra K SchwarczNancy A Hessol
Oct 15, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anne K MonroeTodd T Brown
Oct 18, 2014·Journal of the American Heart Association·Julie A WomackMatthew S Freiberg
Jun 13, 2015·BMC Infectious Diseases·Barbara SuligoiDiego Serraino
Jun 18, 2015·PloS One·Marie-Anne VandenhendeUNKNOWN ANRS EN20 Mortalité 2010 study group
Apr 27, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Antonella ZucchettoDiego Serraino
Jul 23, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David B HannaSarah L Braunstein
May 20, 2017·Population Health Metrics·Enrico GrandeLuisa Frova

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