Excess neutrophil infiltration during cytomegalovirus brain infection of interleukin-10-deficient mice.

Journal of Neuroimmunology
Manohar B MutnalJames R Lokensgard

Abstract

Wild-type mice control murine cytomegalovirus (MCMV) brain infection, but identical infection is lethal to animals deficient in interleukin (IL)-10. Here, we report that MCMV-infected IL-10 knockout (KO) mice displayed a marked increase in neutrophil infiltration into the infected, IL-10-deficient brain when compared to wild-type animals. Enhanced microglial cell activation, determined by MHC class II up-regulation, overexpression of CXCL2, and elevated P-selectin mRNA levels were observed. In vivo blocking of CXCL2 attenuated neutrophil infiltration and significantly improved the outcome of infection. Collectively, these data indicate that the absence of IL-10 results in pathologic neutrophil infiltration into MCMV-infected brains.

References

Jun 1, 1992·Immunology Today·M Howard, A O'Garra
Aug 1, 1986·The Journal of Experimental Medicine·D GiulianL B Lachman
Nov 1, 1996·Molecular Medicine Today·A HaradaK Matsushima
Nov 5, 1998·International Journal of Clinical & Laboratory Research·M A Cassatella
Mar 23, 2000·Respirology : Official Journal of the Asian Pacific Society of Respirology·S Z Wang, K D Forsyth
Jul 6, 2000·Cytokine·T P ShanleyA Denenberg
Jan 4, 2001·Journal of Reproductive Immunology·G N MilliganK L Dudley
Nov 2, 2004·Nature Reviews. Immunology·Kingston H G Mills
Feb 1, 2005·Journal of Virology·Afsar Rahbar, Cecilia Söderberg-Nauclér
Dec 22, 2005·Nature Immunology·Andrew D LusterUlrich H von Andrian
Apr 26, 2008·Science·Jennifer M LundAlexander Y Rudensky
Jan 23, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David P StirlingV Wee Yong
May 8, 2009·Journal of Microbiology and Biotechnology·Eui-Suk JeongYang-Kyu Choi
Jul 25, 2009·Journal of Neurovirology·Maxim C-J CheeranJames R Lokensgard

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Citations

Nov 19, 2013·DNA and Cell Biology·Christelle GabrielLisa F P Ng
Jun 4, 2014·Glia·Scott J SchachteleJames R Lokensgard
May 14, 2016·Journal of Virology·Yuhei MaruzuruYasushi Kawaguchi
Oct 6, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Yajarayma J Tang-FeldmanClaire Pomeroy
Aug 23, 2019·Chinese Medical Journal·Xin-Yan Zhang, Feng Fang
Nov 12, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Manohar B MutnalJames R Lokensgard
Feb 15, 2019·Frontiers in Immunology·Mathew Clement, Ian R Humphreys

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