PMID: 9450852Feb 5, 1998Paper

Excess of mild errors of morphogenesis in childhood lymphoblastic leukemia

American Journal of Medical Genetics
K MéhesD Niethammer

Abstract

The prevalence of 55 well-defined mild errors of morphogenesis (MEMs) was determined in 100 children with acute lymphoblastic leukemia (ALL), their 80 sibs, 91 mothers, and 76 fathers. Seventy-four patients were treated in Pécs (Hungary) and 26 in Tübingen (Germany). Only white Caucasian index cases were included in the study. Two-hundred children examined for acute infections served as controls. In addition, we analyzed the family history for birth defects and malignancies, associated major malformations, birth weight, birth order, and pretreatment height of the patients. The results of the Pécs and Tübingen patients were at first evaluated separately but since no differences were found only the cumulative data were analyzed further. A significantly increased prevalence of MEMs was found in the ALL patients and their sibs of both sexes: their MEM/subject ratios were 1.59 and 1.51, respectively, whereas the same parameter was 0.74 in the mothers, 0.67 in the fathers and 0.69 in the controls. The same tendency was observed when familial cases and/or age-dependent MEMs were excluded and when malformation-type and variant-type MEMs were evaluated separately. No association of ALL with specific MEMs or combinations was recorded. Fa...Continue Reading

Citations

May 20, 2005·American Journal of Epidemiology·Camilla BilleKaare Christensen
Oct 3, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Amy M LinaberyJulie A Ross
Aug 6, 2003·American Journal of Medical Genetics. Part a·György Kosztolányi, Károly Méhes
Sep 23, 2010·Pediatric Blood & Cancer·Funda Erkasar CitakAhmet Emin Kurekci
Jun 29, 2010·American Journal of Medical Genetics. Part a·Lewis B Holmes
Mar 2, 2011·Pediatric Blood & Cancer·Asude DurmazOzgur Cogulu
May 2, 2006·Acta Biologica Hungarica·Kinga HadzsievK Méhes
Feb 26, 2014·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·S A Estrada-PadillaA Corona-Rivera

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.