PMID: 11343319May 9, 2001Paper

Excess paternal age in apparently sporadic osteogenesis imperfecta

American Journal of Medical Genetics
A BlumsohnC R Paterson

Abstract

The objective of this study was to examine whether parental age is associated with the occurrence of apparently sporadic osteogenesis imperfecta (OI). We compared parental age and the joint distribution of maternal and paternal age with expected distributions based on statutory birth records for each year and location of birth. The study included patients with OI based in the United Kingdom. The study was restricted to cases born in England, Wales, and Scotland between 1961 and 1998. Subgroup analysis was by clinical type [Sillence et al., 1979: J Med Genet 16:101-116] and apparent mode of inheritance based on pedigree analysis. Of 730 eligible cases, 357 were apparently sporadic. The mean age of fathers at birth of children with apparently sporadic OI was 0.87 years greater than expected (P = 0.010; 95% confidence interval = 0.21 to 1.54 years). The relative risk was 1.62 for fathers in the highest quintile of paternal age compared with fathers in the lowest quintile. The magnitude of the paternal age excess did not differ significantly between Sillence types (analysis of variance P = 0.534). In sporadic cases, paternal age was 0.51 years greater than expected, given maternal age, year, and location of birth (P = 0.033). In co...Continue Reading

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Citations

Jun 19, 2004·Annals of Human Biology·Ariane Kemkes-Grottenthaler
Mar 2, 2013·Journal of Children's Orthopaedics·Mona S AglanSamia A Temtamy
Jun 28, 2008·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·G BaujatM Le Merrer
May 1, 2015·Reproductive Biology and Endocrinology : RB&E·Rakesh SharmaRola F Turki
Mar 22, 2013·Biology of Reproduction·Jamila R MomandChristi A Walter
May 19, 2018·Current Urology Reports·Daniel J Mazur, Larry I Lipshultz
Feb 23, 2007·Journal of Pediatric Orthopedics·Michael G VitaleDavid P Roye
Aug 15, 2006·Clinical Orthopaedics and Related Research·Colin R Paterson, Susan J McAllion
Aug 21, 2004·Human Reproduction·P AstolfiL A Zonta
Jul 11, 2021·Mechanisms of Ageing and Development·Lucía Chico-SordoElisa Varela

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