Excess Soluble fms-like Tyrosine Kinase 1 Correlates With Endothelial Dysfunction and Organ Failure in Critically Ill Coronavirus Disease 2019 Patients.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Vincent DupontPhilippe Nguyen

Abstract

Excess soluble fms-like tyrosine kinase 1 (sFlt-1), a soluble inhibitor of vascular endothelial growth factor pathway, has been demonstrated to promote endothelial dysfunction. Here, we demonstrate that sFlt-1 plasma levels correlate with respiratory symptom severity, expression of endothelial dysfunction biomarker, and incidence of organ failure in coronavirus disease 2019 patients. Clinical Trials Registration: NCT04394195.

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Citations

Sep 18, 2020·Oncoimmunology·Cléa MelenotteLaurence Zitvogel
Oct 16, 2020·Angiogenesis·Alexandros RovasPhilipp Kümpers
Feb 20, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·José L Eguiburu-JaimeElena A López-Jiménez
Jan 31, 2021·The Journal of Infectious Diseases·Ming TongYimin Zhu
Mar 12, 2021·Atherosclerosis·Thiago QuinagliaAndrei C Sposito
Apr 15, 2021·Primary Care Diabetes·Nalini GovenderThajasvarie Naicker
Jun 30, 2021·Angiogenesis·David M SmadjaArjan W Griffioen
Oct 9, 2021·Scientific Reports·Marilena GrecoGiambattista Lobreglio

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