Excessive breathlessness in patients with diastolic heart failure.

Heart
K K A WitteA L Clark

Abstract

To establish the prevalence of preserved left ventricular (LV) systolic function (PSF) in 435 consecutive symptomatic patients referred to a heart failure clinic and to examine their ventilatory response to exercise when compared with 134 control volunteers. 216 (50%) patients had systolic heart failure (SHF) (ejection fraction < 45%). 51 (11%) had an immediately apparent alternative causes of breathlessness and 168 (39%), with no obvious other cause of breathlessness, were divided into those with PSF and diastolic dysfunction (DD) (PSF(DD); n = 113 or 26% of referrals) and those without DD (PSF(N); n = 55 or 13% of referrals). The controls were divided into those with (C(DD); n = 32) and those without (C(N); n = 102) echocardiographic evidence of DD. Patients with SHF had lower peak oxygen consumption (pVo(2)), steeper slope of minute ventilation (Ve) to carbon dioxide production, lower exercise time and shorter 6 min walk test than PSF patients and controls. PSF(DD) patients had lower pVo(2), exercise time and 6 min walk test than C(DD), although their echocardiograms were not different. Exercise capacity did not differ between PSF(DD) and PSF(N) patients. The slope relating Ve to symptoms (Borg/Ve slope) was less steep in th...Continue Reading

References

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Citations

Oct 12, 2010·Journal of Cardiovascular Translational Research·Rodolphe P KatraImad Libbus
Aug 12, 2014·Journal of Cardiac Failure·Nicholas E Houstis, Gregory D Lewis
Aug 13, 2013·Herz·F Edelmann, B Pieske
Sep 2, 2008·Heart Failure Reviews·A BarmeyerT Meinertz
Apr 22, 2010·Expert Review of Respiratory Medicine·William W Stringer
Mar 19, 2013·The American Journal of the Medical Sciences·Nadish GargMartin A Alpert
Aug 12, 2009·Thérapie·Alain Cohen SolalJean-Michel Tartiere
Aug 4, 2009·Research in Nursing & Health·Corrine Y JurgensUNKNOWN Heart Failure Quality of Life Trialist Collaborators
Aug 26, 2010·Journal of Advanced Nursing·Luciana C PalharesRoberta C M Rodrigues
Nov 29, 2011·European Journal of Heart Failure·Gnanadevan MahadevanMichael Frenneaux
Jun 23, 2015·Current Problems in Cardiology·Jonathan MyersMarco Guazzi
Mar 14, 2009·Journal of the American College of Cardiology·Micha T Maeder, David M Kaye
Apr 28, 2012·Journal of the American College of Cardiology·Marco Guazzi, Alessandra Vitelli
Mar 12, 2016·Postgraduate Medical Journal·Emily E Irizarry PagánAngel López-Candales
Jun 9, 2009·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Thanh Trung PhanMichael Frenneaux
Nov 19, 2010·Postgraduate Medicine·Daniel E FormanRoss Arena

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