PMID: 9441121Jun 1, 1997Paper

Excessive bronchoconstriction induced by histamine and effects of volume history in patients with bronchial asthma

Respirology : Official Journal of the Asian Pacific Society of Respirology
T K Lim, S M Ang

Abstract

The aim of this study was to examine the inter-relationships between the different effects of deep breaths and histamine provocation on airway function in patients with bronchial asthma. Group 1 consisted of 38 consecutive out-patients with newly diagnosed mild asthma, group 2 consisted of 20 patients with bronchial asthma of varying severity who were studied during clinical remission. We measured bronchial responsiveness (BR) to histamine inhalation as the dose of histamine which provoked a 20% fall in FEV1 (PD20). The fall in forced vital capacity (FVC) after inhaling the highest dose of histamine during each BR test was calculated and expressed as percentage of the value measured at baseline (delta FVC in percentage). We studied the effects of deep breaths on airway caliber in group 2 patients by comparing isovolumic flow rates on partial (P) and maximal (M) forced expiratory flow volumes curves expressed as the M/P ratio. The changes in residual volume (RV) after deep breaths (delta RV) were expressed as a percentage of the largest VC measured on the composite M and P curves. The patients in group 1 had significantly higher PD20 and lower delta FVC than patients in group 2. There was, however, no significant correlation bet...Continue Reading

References

Sep 1, 1992·The American Review of Respiratory Disease·T J WilliamsG Bowes
May 1, 1991·The American Review of Respiratory Disease·P D ParéC Bosken
May 1, 1990·The Medical Clinics of North America·A J Woolcock, C R Jenkins
Aug 1, 1989·The American Review of Respiratory Disease·L K JosephsS T Holgate
Dec 1, 1986·Journal of Applied Physiology·J G KirbyN Zamel
Mar 1, 1987·The American Review of Respiratory Disease·T K LimR H Ingram
Nov 1, 1985·Journal of Applied Physiology·C B BurnsR H Ingram
Sep 1, 1968·Journal of Applied Physiology·H F Froeb, J Mead
Aug 1, 1966·The American Journal of Medicine·A J Woolcock, J Read
May 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J E FishV I Peterman
Aug 1, 1981·The Journal of Allergy and Clinical Immunology·A B MurrayB Morrison
Nov 1, 1995·The Journal of Clinical Investigation·G SklootA Togias
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine·D M LougheedD E O'Donnell
May 1, 1995·American Journal of Respiratory and Critical Care Medicine·T C Corbridge, J B Hall
Aug 1, 1994·American Journal of Respiratory and Critical Care Medicine·R PellegrinoV Brusasco
Feb 1, 1994·American Journal of Respiratory and Critical Care Medicine·P L EnrightD W Cockroft
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·P T Macklem
Feb 1, 1996·American Journal of Respiratory and Critical Care Medicine·W J GibbonsP T Macklem
Jul 1, 1961·Journal of Applied Physiology·J A NADEL, D F TIERNEY
Oct 1, 1962·Der Tuberkulosearzt·W LUECKERATH

❮ Previous
Next ❯

Citations

Jun 6, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Luis PrietoJulio Marín
Feb 20, 2007·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Sun Hee ChoiYoung Yull Koh
Mar 17, 2007·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Young YooYoung Yull Koh
Apr 26, 2001·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·T OgaA Ikeda

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

© 2021 Meta ULC. All rights reserved