PMID: 11318821Apr 25, 2001Paper

Excessive exercise ventilation in moderate left heart dysfunction. Influence of postural changes in central haemodynamics and blood gases

Clinical Physiology
H E RefsumO K Müller

Abstract

To evaluate the relative importance of pulmonary congestion and peripheral hypoxia as causes for the excessive exercise ventilation in left heart dysfunction, seven patients with excessive ventilation and distinct left heart dysfunction during moderate exercise (LHD), and seven control patients with essentially normal exertional functions (CTR), had ventilation, central haemodynamics, arterial and mixed venous blood gases examined at rest and exercise, 32 W (25-40) in the LHD group and 44 W (33-49) in the CTR group, in lying and sitting positions. Change from lying to sitting exercise, led to fall in pulmonary artery wedge pressure (PAWP) from 31.0 +/- 5.5 to 8.8 +/- 5.0 mmHg in the LHD group, compared with from 13.7 +/- 1.0 to 2.1 +/- 2.4 mm Hg in the controls, while ventilation/O2 intake ratio (V/VO2) and physiological dead space/tidal volume ratio (VD/VT) showed a tendency to rise, from 36.3 +/- 8.8 to 39.2 +/- 7.4, and from 0.35 +/- 0.11 to 0.39 +/- 0.09, respectively, in the LHD group, and from 27.5 +/- 3.1 to 28.7 +/- 5.3, and from 0.19 +/- 0.09 to 0.21 +/- 0.12 in the controls. Mixed venous O2 tension (PvO2) showed a marked decline from 3.60 +/- 0.33 to 3.26 +/- 0.36 kPa in the LHD group, as compared with from 3.94 +/- 0...Continue Reading

References

Sep 1, 1976·Progress in Cardiovascular Diseases·R Ingram, E R McFadden
Sep 1, 1992·American Heart Journal·J MyersV F Froelicher
Mar 1, 1987·Clinical Cardiology·D L CotsamireC V Leier
Feb 1, 1986·The American Journal of Cardiology·L I FinkN Ferraro
Mar 1, 1985·Respiration Physiology·F L EldridgeT G Waldrop
Apr 1, 1985·Clinical Physiology·I NordenfeltS Olsson
Dec 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·H E Refsum
Jan 1, 1966·British Heart Journal·N GazetopoulosD Deuchar
May 1, 1995·European Journal of Clinical Investigation·A L ClarkA J Coats
Jul 1, 1995·Progress in Cardiovascular Diseases·M J Sullivan, M H Hawthorne
May 1, 1995·Progress in Cardiovascular Diseases·D M Mancini
Mar 1, 1996·Journal of the American College of Cardiology·T P ChuaA J Coats
May 1, 1997·Current Opinion in Cardiology·D Harrington, A J Coats
Jan 1, 1952·Scandinavian Journal of Clinical and Laboratory Investigation·H ERIKSON

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