Excessive glutamine sensitivity in Alzheimer's disease and Down syndrome lymphocytes

Journal of the Neurological Sciences
M A PeetersJ Lejeune

Abstract

In addition to clinical and neuropathological similarities between Alzheimer's disease and Down syndrome there are genetic and biochemical data which suggest common disease mechanism. Using an in vitro assay examining variations of the mitotic index in the presence or absence of various inhibitors or metabolites of purine and/or pyrimidine synthesis, we studied 19 Alzheimer disease patients and 16 patients with both Down syndrome and Alzheimer type dementia. A highly significant decrease in mitotic index in the presence of exogenous glutamine was noted in patients presenting an Alzheimer type dementia with or without associated Down syndrome. These findings suggest that glutamine sensitivity or some dysregulation of the glutamine/glutamate pathway may play a role in the pathogenesis of Alzheimer's disease. If these findings are confirmed, they would have important implications in the development of preventive strategies.

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Citations

Jan 5, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Svjetlana Kalanj-BognarCedomir Cosović
Jul 29, 2003·Current Opinion in Critical Care·Jan Wernerman
Jul 14, 2001·The American Journal of Clinical Nutrition·A L Buchman
Dec 9, 2004·The American Journal of Clinical Nutrition·Nathalie Fillon-EmeryJean Pierre Nicolas
Aug 11, 2015·Mutation Research·Mirta MilicStefano Bonassi

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