Excessive mortality and causes of death among patients with personality disorder with comorbid psychiatric disorders

Social Psychiatry and Psychiatric Epidemiology
Chian-Jue KuoChiao-Chicy Chen

Abstract

Excessive mortality has been seen in patients with personality disorder (PD), but it has not been well-studied when patients also have other psychiatric comorbidities. This study investigated the mortality rates and causes of death in an Asian cohort with PD. We enrolled patients ≥ 18 years of age with PD as defined by DSM-IV criteria (N = 1172), who had been admitted to a psychiatric service center in northern Taiwan between 1985 and 2008. By linking with the national mortality database (1985-2008), cases of mortality (n = 156, 13.3%) were obtained. We calculated the standardized mortality ratios (SMRs) to estimate the mortality gap between patients with PD and the general population. Stratified analyses of mortality rates by Axis I psychiatric comorbidity and sex were performed. Borderline PD (n = 391, 33.4%) was the dominant disorder among the subjects. The SMRs for all-cause mortality of PD alone, PD comorbid with non-substance use disorder(non-SUD), and PD comorbid with SUD were 4.46 (95% CI 1.94-6.98), 7.42 (5.99-8.85), and 15.96 (11.07-20.85), respectively. Among the causes of death, the SMR for suicide was the highest (46.92, 95% CI 34.29-59.56). The SMR for suicide in PD patients with comorbid SUD was unusually high (7...Continue Reading

References

Jul 1, 1994·The American Journal of Psychiatry·J F SamuelsP R McHugh
Mar 1, 1993·The British Journal of Psychiatry : the Journal of Mental Science·M H Stone
May 1, 1997·The British Journal of Psychiatry : the Journal of Mental Science·A T ChengK A Chan
Jul 9, 1999·Social Psychiatry and Psychiatric Epidemiology·P Moran
Sep 15, 1999·The American Journal of Psychiatry·J C PerryF Ianni
Mar 18, 2000·Clinical Psychology Review·T J TrullR Burr
Jun 29, 2002·The Journal of Clinical Psychiatry·Shang-Ying M TsaiHsin-Chien Lee
Nov 6, 2004·BMC Psychiatry·Geneviève Arsenault-LapierreGustavo Turecki
May 14, 2005·The Journal of Clinical Psychiatry·Chian-Jue KuoChiao-Chicy Chen
Mar 2, 2011·Drug and Alcohol Review·Chian-Jue KuoChiao-Chicy Chen
Jun 3, 2011·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Marc De HertChristoph U Correll
Jul 14, 2012·Journal of Psychosomatic Research·Marcella Lei-Yee FokPaul Moran
Aug 24, 2013·The British Journal of Psychiatry : the Journal of Mental Science·Casey CrumpJan Sundquist
Apr 1, 2014·Psychiatry Research·Shi-Kwang LinChian-Jue Kuo
May 6, 2014·Deutsches Ärzteblatt International·Thorsten KienastKlaus Lieb
Jun 4, 2014·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Edward ChesneySeena Fazel
Dec 3, 2014·Drug and Alcohol Dependence·Chun-Hung PanChian-Jue Kuo
Jan 13, 2015·Drug and Alcohol Dependence·Karolina M BogdanowiczRichard D Hayes
Jul 15, 2015·The British Journal of Psychiatry : the Journal of Mental Science·Emma BjörkenstamLisa Ekselius
Dec 31, 2015·The Journal of Clinical Psychiatry·Galen Chin-Lun HungChian-Jue Kuo
May 28, 2016·The Journal of Clinical Psychiatry·Jens D BukhLars V Kessing
Aug 24, 2016·Journal of Psychiatric Research·Charlotte BjörkenstamEmma Björkenstam
Oct 4, 2016·Psychiatric Services : a Journal of the American Psychiatric Association·Matthew C LohmanWinifred R Christ
Aug 20, 2015·BJPsych Open·Charlotte BjörkenstamLisa Ekselius
Feb 28, 2018·Substance Abuse Treatment, Prevention, and Policy·Louise PenzenstadlerUeli Kramer
Apr 9, 2018·European Addiction Research·Malahat KhaliliMasoumeh Amin-Esmaeili

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