Excessive phase synchronization in cortical activation during locomotion in persons with Parkinson's disease

Parkinsonism & Related Disorders
Yael Miron-ShaharMeir Plotnik

Abstract

Parkinson's disease (PD) is characterized by gait disturbances, which become severe during the advanced stages of the disease. Though gait impairments in Parkinson's disease have been extensively described in terms of spatiotemporal gait parameters, little is known regarding associated patterns of cortical activity. The objective of the present study is to test if interhemispheric synchronization differs between participants with PD and healthy elderly controls (NPD). We analyzed electroencephalography (EEG) signals recorded during bilateral movements, i.e., locomotion and hand tapping. Fifteen participants with PD ('OFF' their anti-parkinsonian medications) and eight NPD were assessed during quiet standing, straight-line walking, turning, and hand tapping tasks. Using a 32-electrode EEG array, we quantified the synchronization in periodic cortical activation between the brain hemispheres (interhemispheric phase synchronization; inter-PS). Theta, alpha, beta, and gamma bands were evaluated. In all bands, inter-PS was significantly higher for the PD group as compared with the NPD group during standing and walking (p < 0.001) and during bimanual tasks (p = 0.026). Persons with PD exhibit increased inter-PS as compared with NPD pa...Continue Reading

Citations

Feb 14, 2020·Brain Sciences·Arnaud DelvalKathy Dujardin
Nov 17, 2020·Frontiers in Human Neuroscience·Doris D Wang, Julia T Choi
May 18, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mark HallettPaolo M Rossini
Aug 3, 2021·Frontiers in Computational Neuroscience·Carlos Coronel-OliverosPatricio Orio

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