PMID: 707889Oct 1, 1978

Excessive polycythemia of high altitude: role of ventilatory drive and lung disease

The American Review of Respiratory Disease
M KrygerRobert F Grover

Abstract

Persons residing at high altitude who develop excessive polycythemia are more hypoxemic than normal high-altitude residents. We investigated the causes of hypoxemia in 20 patients with excessive polycythemia residing at an altitude of 3,100 m. Lung disease evidenced by abnormal spirometric features and results of a respiratory questionnaire was present in 10 of 20 patients and resulted in increased alveolar-arterial difference for PO2 [(A-a)PO2]. The excessive hypoxemia in the patients with normal lungs was not due to increased (A-a)PO2. We measured ventilatory responses to hypoxia and to hypercapnia to determine whether blunting of these responses was a cause of this excessive hypoxemia. We found, however, that chemical drives to breathe, although blunted, were the same in patients with polycythemia as in high-altitude control subjects. However, an abnormal breathing pattern was observed; the polycythemic patients had a smaller tidal volume and a greater ratio of dead space to tidal volume than did the normal subjects. In addition, the polycythemic patients had increased minute ventilation on breathing 100 percent O2, whereas the normal subjects did not. Thus, hypoxic depression of ventilation may have been present. Our findin...Continue Reading

Citations

Jun 1, 1994·The American Journal of the Medical Sciences·C C Hsia
Feb 6, 2013·Respiratory Physiology & Neurobiology·Colleen Glyde JulianLorna G Moore
Apr 27, 2010·Progress in Cardiovascular Diseases·F Leon-VelardeJean-Paul Richalet
Apr 3, 2010·Journal of Science and Medicine in Sport·Robert F ChapmanBenjamin D Levine
Aug 21, 2007·Respiratory Physiology & Neurobiology·Lorna G MooreEnrique Vargas
Jan 3, 2006·Respiratory Physiology & Neurobiology·Lorna G Moore, Robert F Grover
Sep 1, 1987·Annals of Emergency Medicine·L G Moore
Jul 8, 2008·Respiratory Physiology & Neurobiology·Maria Rivera-ChF Leon-Velarde
Jul 20, 2004·Journal of Applied Physiology·Tianyi WuZhigang Wang
Jan 9, 1999·American Journal of Physical Anthropology·L G MooreS Zamudio
Feb 7, 1998·American Journal of Physical Anthropology·C M BeallC Gonzales
Jan 1, 1990·American Journal of Human Biology : the Official Journal of the Human Biology Council·Robert M WinslowCarlos Monge C
Aug 3, 2005·High Altitude Medicine & Biology·F Leon-VelardeGustavo Zubieta-Calleja
Oct 30, 2001·High Altitude Medicine & Biology·R Vásquez, M Villena
Jul 10, 2001·High Altitude Medicine & Biology·L G Moore
Aug 31, 1999·Women & Health·J J KurinczukP R Burton
Oct 18, 2014·Journal of Applied Physiology·Francisco C VillafuerteF Leon-Velarde
Feb 24, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·F Leon-VelardeC Monge-C
Feb 14, 1998·Journal of Applied Physiology·L S CurranL G Moore
Feb 8, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Vincent JosephJean Marc Pequignot
Jul 1, 1994·Annals of Saudi Medicine·M S Al-HajjajF A Al-Kassimi

Related Concepts

Altitude
Anoxemia
Bronchitis
Carbon Dioxide
Hypoventilation
Lung Diseases
Dioxygen
Erythrocytosis
Respiration
Respiratory Dead Space

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.