PMID: 9433378Jan 20, 1998Paper

Excessive prolongation of the bleeding time by aspirin in essential thrombocythemia is related to a decrease of large von Willebrand factor multimers in plasma

Annals of Hematology
P J van GenderenJ J Michiels

Abstract

Patients with essential thrombocythemia (ET), who frequently have bleeding complications, may manifest an excessive prolongation of the bleeding time (BT) after ingestion of aspirin (ASA). The reason for this excessive prolongation of the BT is unknown, but it is attributed to qualitative platelet defects. Since patients with ET may also have acquired abnormalities of plasma and platelet von Willebrand factor (vWF), we questioned whether the excessive prolongation of the BT by ASA was related to changes in either plasma or platelet vWF. To that end, we studied BT and plasma and platelet vWF in ten ET patients, ten patients with reactive thrombocytosis (RT), and ten normal individuals, both before and after administration of 500 mg ASA for 7 days. In a second study, the effect of DDAVP infusion on plasma vWF in relation to the BT was studied in ten normal individuals and ten ET patients after treatment with 100 mg ASA for 3 days. In the first study, treatment with ASA resulted in a significant prolongation of the BT in normal subjects, RT patients, and ET patients. However, in five ET patients an excessive (> 2 SD) prolongation of the BT by ASA was observed. Although ASA induced no direct changes in either plasma or platelet vWF...Continue Reading

Citations

May 24, 2003·Best Practice & Research. Clinical Haematology·Michelle A Elliott, Ayalew Tefferi
May 15, 2013·Expert Opinion on Pharmacotherapy·Gunnar Birgegård
Nov 19, 2015·Expert Review of Hematology·Ulrich BuddeRita Dittmer
Sep 8, 2009·Progress in Cardiovascular Diseases·Udaya S TantryPaul A Gurbel
Jan 26, 2005·British Journal of Haematology·M A Elliott, A Tefferi
Aug 9, 2016·Current Hematologic Malignancy Reports·Gunnar Birgegård
Jun 1, 2010·European Journal of Pain : EJP·James A BlunkMartin Schmelz
Mar 22, 2000·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·J J Michiels
Jul 3, 2015·Therapeutic Advances in Hematology·Gunnar Birgegård
Nov 30, 2006·American Journal of Hematology·Massimo Franchini, Giuseppe Lippi
Mar 17, 2007·Critical Reviews in Clinical Laboratory Sciences·Massimo Franchini, Giuseppe Lippi
Aug 5, 2020·Neurocritical Care·Lise Kjær AndersenChristine Lodberg Hvas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Baillière's Clinical Haematology
Jean Brière, N el-Kassar
Aviation, Space, and Environmental Medicine
Russell B Rayman
Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research
Regina MendonçaMárcio Ajudarte Lopes
© 2021 Meta ULC. All rights reserved