Excessive weight gains in female rats with transections of the stria terminalis

Physiology & Behavior
B M KingLeslie G Olivier

Abstract

Recent studies have demonstrated hyperphagia and excessive weight gains in female rats with small lesions in the most posterodorsal aspects of the medial amygdala. In the present study, similar results were observed in female rats with bilateral transections of the stria terminalis just as it exits the amygdala to begin its dorsal ascent (mean weight gain of 35.9 g/20 days compared to 0.1 g/20 days for operated control animals). Cellular damage caused by the retractable wire knife was limited to the caudal globus pallidus. The results of previous studies that failed to observe weight gains after stria terminalis transections were attributed to the use of male animals. The present results, along with the pattern of anterograde degeneration that is observed after obesity-inducing amygdaloid lesions, suggest a medial amygdala-stria terminalis-medial hypothalamic pathway in the regulation of food intake and body weight, but other possibilities are considered.

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Citations

Jul 4, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Lori Asarian, Nori Geary
Sep 25, 2007·Physiology & Behavior·Edward A PankeyBruce M King
Oct 15, 2008·The Journal of Comparative Neurology·Jung-Won ShinArthur D Loewy
Jul 18, 2006·Physiology & Behavior·Bethany L RollinsBruce M King
Jul 3, 2010·Anatomia, histologia, embryologia·M RówniakM Majewski
Nov 23, 2017·Development and Psychopathology·Layla BanihashemiRyan J Herringa
Jun 17, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bruce M King
Aug 2, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lori Asarian, Nori Geary
Feb 9, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Scott J GrundmannBruce M King

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