Abstract
To compare the efficacy of exchange transfusion as the adjunct to quinine treatment (21 patients) with quinine therapy alone (29 patients). A retrospective study of 50 patients with severe falciparum malaria was conducted at Chumphorn Hospital, Southern Thailand. Clinical characteristics in both treatment groups were not significantly different although in the exchange transfusion group, the admission geometric mean parasitaemia (18 (5%), and the proportion of patients with more than 10% parasitaemia was higher (76%, P = 0.03) than in the group who received quinine alone (10 +/- 4%; 38%, P = 0.1). The mortality rate of patients who received exchange transfusion was 48%; that of the remainder, 69%. (P = 0.3). ARDS (P = 0.01) and oliguric renal failure (P = 0.04) were significant risk factors for death in these patients. Exchange transfusion was safe and well tolerated. Results of our study revealed a 20% reduction in mortality when exchange transfusion was used as an adjunct to quinine treatment. It should therefore be considered in patients with severe falciparum malaria when possible.
Citations
Mar 14, 2000·The Journal of Infection·N J White
Oct 20, 2006·The New England Journal of Medicine·Iain P FraserWalter H Dzik
Apr 10, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mark S RiddleDavid L Blazes
Mar 12, 1999·Annual Review of Medicine·P Newton, N White
Aug 28, 2010·Journal of Obesity·Claire E WilcoxWilliam J Jagust
Apr 13, 2007·Malaria Journal·Rajagopala SrinivasDheeraj Gupta
Aug 23, 2000·Medicina clínica·C Mirete FerrerF Gutiérrez Rodero
Aug 23, 2006·Anaesthesia·B J L KendrickM P R Watters
Jun 23, 2010·Journal of Clinical Apheresis·Zbigniew M SzczepiorkowskiUNKNOWN Apheresis Applications Committee of the American Society for Apheresis
Dec 17, 2009·Transfusion·Suresh G ShelatMatthew S Braga
Dec 3, 2009·Transfusion·Perry J J van GenderenDavid Overbosch
Jun 6, 2012·Hematology·Karolina S AkinosoglouCharalambos A Gogos
Jul 3, 2002·Clinics in Chest Medicine·Surinder K JindalDheeraj Gupta
Feb 18, 2011·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Krishna Venkatesh BaligaAkhil Nagpal
Apr 17, 2015·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Himesh Barman
Oct 13, 2006·Current Opinion in Infectious Diseases·C J Whitty, F Sanderson
Oct 21, 2006·The Cochrane Database of Systematic Reviews·S Thayyil, D W A Milligan
Oct 29, 2000·Journal of the American Society of Nephrology : JASN·Rashad S Barsoum
Feb 4, 2003·Seminars in Nephrology·Somchai Eiam-Ong
Sep 17, 2005·Pediatrics·Fouad N Boctor