Exchange transfusion with entirely synthetic red-cell substitute albumin-heme into rats: physiological responses and blood biochemical tests

Journal of Biomedical Materials Research. Part a
Yubin HuangEishun Tsuchida

Abstract

Recombinant human serum albumin (rHSA) incorporating 2-[8-[N-(2-methylimidazolyl)]octanoyloxymethyl]-5,10,15,20-[tetrakis[alpha,alpha,alpha,alpha-o-(1-methylcyclohexanoyl)amino]phenyl]porphinatoiron(II) [albumin-heme (rHSA-heme)] is an artificial hemoprotein which has the capability to transport O(2) in vitro and in vivo. A 20% exchange transfusion with rHSA-heme into anesthetized rats has been performed to evaluate its clinical safety by monitoring the circulation parameters and blood parameters for 6 h after the infusion. Time course changes in all parameters essentially showed the same features as those of the control group (without infusion) and rHSA group (with administration of the same amount of rHSA). Blood biochemical tests of the withdrawn plasma at 6 h after the exchange transfusion have also been carried out. No significant difference was found between the rHSA-heme and rHSA groups, suggesting the initial clinical safety of this entirely synthetic O(2)-carrier as a red-cell substitute.

References

Dec 1, 1989·The British Journal of Surgery·P A ClavienA R Moossa
Jan 1, 1997·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·T M Chang
Mar 12, 1999·Annual Review of Medicine·R M Winslow
Feb 9, 2002·Science·Jerry E Squires
Jan 11, 2003·Journal of Biomedical Materials Research. Part a·Eishun TsuchidaMakoto Suematsu
Jul 31, 2003·Journal of Biomedical Materials Research. Part a·Yubin HuangShū Kobayashi

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Citations

Jan 28, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Yubin HuangEishun Tsuchida

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