Excimer laser treatment of vitiligo -- critical retrospective assessment of own results and literature overview

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
Bärbel GreveEdda Fischer

Abstract

In numerous studies the 308-nm excimer laser has been described as an effective therapy method for localized vitiligo. Our experience and critical evaluation of the relevant literature lead to a less enthusiastic endorsement. A total of 9 patients with localized vitiligo were evaluated in our retrospective study. The sessions took place 2-3 times per week; the energy dose was increased depending on the occurring side effects. The rate of repigmentation was evaluated in 5 grades: grade 0 = 0 %, grade 1 = 1-25 %, grade 2 = 26-50 %, grade 3 = 51-75 %,grade 4 = 76-100 %. Subjective patient satisfaction was rated "satisfied"/"not satisfied". In face and neck areas we used a cumulative energy dose of 16.6 J/cm(2) and achieved repigmentation grade 4 in 33.3 %, grade 2 in 33.3 %, grade 1 in 11.1 % and no improvement in 22.2 % of the cases. On hands and knees we used a medium cumulative energy dose of 20.8 J/cm(2) and did not observe any tendency towards repigmentation. Four of the patients were satisfied, while 5 were not. Side effects (erythema, blisters, crusting and perilesional hyperpig-mentation) were transient in all cases. Within a medium observation period of 19.1 months, one patient had a relapse. The excimer laser should be r...Continue Reading

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Aug 16, 2012·Lasers in Medical Science·Alauldin Khalef AlhowaishKlaus Fritz
Nov 3, 2007·Photomedicine and Laser Surgery·Zhu ShenYu-Feng Liu
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