PMID: 737187Dec 21, 1978Paper

Excision repair in ataxia telangiectasia, Fanconi's anemia, Cockayne syndrome, and Bloom's syndrome after treatment with ultraviolet radiation and N-acetoxy-2-acetylaminofluorene

Biochimica Et Biophysica Acta
F E Ahmed, R B Setlow

Abstract

Excision repair of damage due to ultraviolet radiation, N-acetoxy-2-acetyl-aminofluorene and a combination of both agents was studied in normal human fibroblasts and various cells from cancer prone patients (ataxia telangiectasia, Fanconi's anemia, Cockayne syndrome and Bloom's syndrome). Three methods giving similar results were used: unscheduled DNA synthesis by radioautography, photolysis of bromodeoxyuridine incorporated into parental DNA during repari, and loss of sites sensitive to an ultraviolet endonuclease. All cell lines were proficient in repair of ultraviolet and acetoxy acetylaminofluorene damage and at saturation doses of both agents repair was additive. We interpret these data as indicating that the rate limiting step in excision repair of ultraviolet and acetoxy acetylaminofluorene is different and that there are different enzyme(s) working on incision of both types of damages.

References

Apr 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F E Ahmed, R B Setlow
Feb 23, 1978·Nature·R B Setlow
Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·E Seeberg
Feb 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·R Hand, J German
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J F Remsen, P Cerutti
Jul 19, 1974·Nature·P K PoonJ W Parker

Citations

Jan 1, 1980·Radiation and Environmental Biophysics·F E Ahmed
Jan 1, 1993·Molecular Neurobiology·K S Rao
Feb 1, 1980·Mutation Research·A B KrepinskyJ A Heddle
Apr 1, 1981·Mutation Research·F GiannelliP K Botcherby
Dec 1, 1982·Mutation Research·A R Lehmann
Nov 1, 1982·Mutation Research·L V MayneR Waters
Jul 1, 1984·Cancer Genetics and Cytogenetics·S Ved BratH Dosik
Jun 1, 1984·Cancer Genetics and Cytogenetics·D LerouxP Jalbert
May 1, 1984·Mutation Research·G J HookJ A Heddle
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·I Emerit, P Cerutti
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S T WarrenJ E Trosko
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·U MallickP Herrlich
Jul 1, 1987·European Journal of Cancer & Clinical Oncology·E Kovacs, A Almendral
Jun 1, 1982·Experimental and Molecular Pathology·R YataniS Takeda
Jun 1, 1980·Clinical and Experimental Dermatology·F Giannelli
May 1, 1983·Photochemistry and Photobiology·C D LytleJ H Robbins
May 1, 1979·Photochemistry and Photobiology·F E Ahmed, R B Setlow
Sep 1, 1988·International Journal of Radiation Biology·J S Rubin

Related Concepts

Ataxia Telangiectasia
NSC-38297
Alkaline DNase
DNA, Double-Stranded
Base Excision Repair
Dwarfism
Endonuclease
De Toni-Debre-Fanconi Syndrome
Fibroblasts
Photodegradation

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.