PMID: 6985718Jan 10, 1980Paper

Excision sequences in the mitochondrial genome of yeast

Nature
C GaillardG Bernardi

Abstract

It is well established that spontaneous cytoplasmic 'petite' mutants of Saccharomyces cerevisiae have mitochondrial genome units in which an excised segment of the parental wild-type genome has been tandemly amplified (Fig. 1), so that the excised segment becomes the repeat unit of the petite genome; the latter may in turn undergo further deletions leading to secondary petite genomes having shorter repeat units (see ref. 1 for a brief review). Recent investigations on the mitochondrial genomes of several spontaneous petite mutants have shown that frequently the ends of the excised segment correspond to short sequences of the wild-type genome which are extremely rich in GC, the GC clusters; alternatively, they seem to be located in the long AT-rich stretches, the AT spacers, which form at least half of the genome. As sequence repetitions have been demonstrated in both GC clusters and AT spacers, it is very likely that excision takes place by a mechanism involving illegitimate site-specific recombination events between homologous sequences, as previously postulated. We show here that the sequences involved in the excision of a particular spontaneous petite genome are direct nucleotide repeats located in the AT spacers.

References

Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G Macino, A Tzagoloff
Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·L A HensgensJ L Bos
Feb 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A M Maxam, W Gilbert
Jul 24, 1979·Molecular & General Genetics : MGG·C Gaillard, G Bernardi
Feb 15, 1977·Journal of Molecular Biology·A Prunell, G Bernardi

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Citations

Apr 1, 1991·Molecular & General Genetics : MGG·G F WeillerR J Schweyen
May 1, 1991·Journal of Molecular Evolution·P J Skelly, G D Clark-Walker
Mar 1, 1983·Gene·M de ZamaroczyG Bernardi
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M E HudspethL I Grossman
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·W L Fangman, B Dujon
Sep 6, 2012·The Journal of Biological Chemistry·Jonathan D NardozziXin Jie Chen
Feb 11, 1985·Nucleic Acids Research·D L MillerN C Martin
Jun 6, 2000·Microbiology and Molecular Biology Reviews : MMBR·V Contamine, M Picard
Feb 1, 1980·Current Genetics·R GoursotG Bernardi
Jun 30, 1980·FEBS Letters·G Bernardi, G Bernardi
Jun 2, 1980·FEBS Letters·G BaldacciG Bernardi
Dec 1, 1980·FEBS Letters·R Grantham
May 1, 1990·Yeast·A B DevinI P Arman
Apr 9, 2015·Frontiers in Genetics·Tiziana LodiEnrico Baruffini
Jan 27, 1983·Nature·F Farrelly, R A Butow
Sep 6, 2013·Microbiology and Molecular Biology Reviews : MMBR·Xin Jie Chen
Apr 1, 1990·Molecular and Cellular Biology·P J Skelly, G D Clark-Walker
May 1, 1987·Journal of Bacteriology·I YamashitaS Fukui
Jun 28, 1985·Science·R A ButowL I Grossman

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