PMID: 6314244Sep 1, 1983Paper

Excitation-contraction coupling in frog ventricle. Possible Ca2+ transport mechanisms

Pflügers Archiv : European journal of physiology
T S Klitzner, M Morad

Abstract

In frog ventricular muscle generation of tension was found to be under direct and continuous control of membrane potential. No phasic component of tension was found at any membrane potential. Developed tension depended only on the duration and amplitude of depolarization and was independent of previous contractile history. Developed tension, in part, depended on Ca2+ influx through a slowly inactivating component of Isi. Using long voltage clamp steps to achieve steady-state tension, no decline or reversal of developed tension was found at ECa. Increasing the [Ca]o shifted the tension-voltage relation to more negative potentials and increased the net outward current at potentials positive to -10 mV. The increase in tension seemed to be related to the increase in outward membrane current and K+ efflux, as estimated from post clamp K+ accumulations. Increasing [K]o, either by clamp-induced K+-accumulation or by increasing the [K] of the bathing solution, decreased the developed tension. These results suggest that in frog ventricular muscle Ca2+ for activation of tension is transported primarily from the extracellular space. There was no trigger-release of internal stores or recirculation of sequestered Ca2+. Activator Ca2+ was tr...Continue Reading

References

Jan 1, 1979·The Journal of Physiology·L Cleemann, M Morad
Aug 1, 1976·The Journal of Physiology·M Horackova, G Vassort
Mar 1, 1975·The Journal of General Physiology·W R Gibbons, H A Fozzard
Jan 1, 1973·Annual Review of Physiology·G A Langer
Jan 1, 1972·Pflügers Archiv : European journal of physiology·G Vassort, O Rougier
Jan 1, 1972·Pflügers Archiv : European journal of physiology·C Léoty, G Raymond
Mar 30, 1973·Pflügers Archiv : European journal of physiology·G Vassort
Jan 1, 1969·Pflügers Archiv : European journal of physiology·O RougierE Coraboeuf
Jan 1, 1972·Pflügers Archiv : European journal of physiology·W New, W Trautwein
Jan 1, 1972·Pflügers Archiv : European journal of physiology·W New, W Trautwein
Jan 1, 1971·Pflügers Archiv : European journal of physiology·R Ochi, W Trautwein
Jan 1, 1968·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·M Morad, W Trautwein
Dec 1, 1971·The Journal of Physiology·M Morad, R K Orkand
Mar 1, 1970·The Journal of Physiology·G W Beeler, H Reuter
Mar 1, 1970·The Journal of Physiology·G W Beeler, H Reuter
Feb 18, 1982·The American Journal of Cardiology·M Morad, L Tung
Oct 1, 1982·Journal of Molecular and Cellular Cardiology·R S Kass, T Scheuer
Sep 1, 1983·Pflügers Archiv : European journal of physiology·T Klitzner, M Morad
Jun 1, 1980·The Journal of Physiology·D A Eisner, W J Lederer
Apr 1, 1956·The American Journal of Physiology·B F HOFFMANE E SUCKLING
Oct 31, 1958·The Journal of Physiology·H C LUTTGAU, R NIEDERGERKE

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Citations

Feb 1, 1991·The American Journal of Physiology·N ShepherdW Spielman
Dec 22, 1999·The American Journal of Physiology·R W Fasciano, L Tung
Sep 24, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matti Vornanen
Nov 5, 2014·Physiology·Holly A Shiels, Gina L J Galli
Oct 1, 1986·Circulation Research·M TarrK K Goertz
Feb 1, 1992·The American Journal of Physiology·G F TibbitsH Kashihara
Feb 1, 1995·Acta Physiologica Scandinavica·H AsgrímssonS A Arnardóttir
Jul 10, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matti Vornanen, Vesa Paajanen
Feb 17, 2006·The Journal of Experimental Biology·Margarita A SalasAlicia Mattiazzi

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