Excitation of tuberoinfundibular dopamine neurons by oxytocin: crosstalk in the control of lactation

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Virginie BriffaudChristian Broberger

Abstract

Milk production in the nursing mother is induced by the hormone prolactin. Its release from the anterior pituitary is generally under tonic inhibition by neuroendocrine tuberoinfundibular dopamine (TIDA) neurons of the arcuate nucleus. Successful nursing, however, requires not only production but also ejection of breast milk. This function is supported by the hormone oxytocin. Here we explored the possibility that interaction between these functionally complementary hormones is mediated by TIDA neurons. First, whole-cell patch-clamp recordings were performed on prepubertal male rat hypothalamic slices, where TIDA neurons can be identified by a robust and rhythmic membrane potential oscillation. Oxytocin induced a switch of this rhythmic activity to tonic discharge through a depolarization involving direct actions on TIDA neurons. The depolarization is sensitive to blockade of the oxytocin receptor and is mediated by a voltage-dependent inward current. This inward current has two components: a canonical transient receptor potential-like conductance in the low-voltage range, and in the high-voltage range, a Ca(2+)-dependent component. Finally, whole-cell and loose-patch recordings were also performed on slices from virgin and lac...Continue Reading

Citations

Aug 25, 2015·Neuropharmacology·Roberto De LucaOlga A Sergeeva
May 7, 2016·Cell Reports·Stefanos StagkourakisChristian Broberger
Oct 21, 2016·Development and Psychopathology·Peter A Bos
Jul 26, 2017·The European Journal of Neuroscience·Miguel DomínguezGabriela González-Mariscal
Aug 18, 2020·Journal of Neuroendocrinology·Rachida Ammari, Christian Broberger
Feb 15, 2017·Proceedings of the National Academy of Sciences of the United States of America·Nicola RomanòPatrice Mollard
Jan 27, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lily R BarrettXiaobing Zhang
Nov 25, 2020·Molecular and Cellular Endocrinology·Yifan NiJinzhi Zhang
Aug 28, 2021·International Journal of Molecular Sciences·Tiago ChavesDóra Zelena

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