Excitatory actions of vasoactive intestinal peptide on mouse thalamocortical neurons are mediated by VPAC2 receptors.

Journal of Neurophysiology
Sang-Hun Lee, Charles L Cox

Abstract

Thalamic nuclei can generate intrathalamic rhythms similar to those observed at various arousal levels and pathophysiological conditions such as absence epilepsy. These rhythmic activities can be altered by a variety of neuromodulators that arise from brain stem regions as well as those that are intrinsic to the thalamic circuitry. Vasoactive intestinal peptide (VIP) is a neuropeptide localized within the thalamus and strongly attenuates intrathalamic rhythms via an unidentified receptor subtype. We have used transgenic mice lacking a specific VIP receptor, VPAC(2), to identify its role in VIP-mediated actions in the thalamus. VIP strongly attenuated both the slow, 2-4 Hz and spindle-like 5-8 Hz rhythmic activities in slices from wild-type mice (VPAC(2)(+/+)) but not in slices from VPAC(2) receptor knock-out mice (VPAC(2)(-/-)), which suggests a major role of VPAC(2) receptors in the antioscillatory actions of VIP. Intracellular recordings revealed that VIP depolarized all relay neurons tested from VPAC(2)(+/+) mice. In VPAC(2)(-/-) mice, however, VIP produced no membrane depolarization in 80% of neurons tested. In relay neurons from VPAC(2)+/+ mice, VIP enhanced the hyperpolarization-activated mixed cation current, I(h), via c...Continue Reading

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Citations

Apr 28, 2007·The Journal of Physiology·Sang-Hun LeeCharles L Cox
Jun 7, 2008·The Journal of Physiology·Sunggu Yang, Charles L Cox
Jun 5, 2007·Trends in Neurosciences·John R Huguenard, David A McCormick
Apr 18, 2015·The European Journal of Neuroscience·Andrew VoskoChristopher S Colwell
Sep 23, 2008·Neuropharmacology·Sang-Hun Lee, Charles L Cox
Jan 23, 2010·The European Journal of Neuroscience·Kush Paul, Charles L Cox
Jun 7, 2013·Journal of Neurophysiology·Takashi KudoChristopher S Colwell
Jan 25, 2022·Expert Review of Neurotherapeutics·Slobodan M Janković, Miralem Đešević

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