PMID: 6105008Aug 25, 1980Paper

Excitatory and inhibitory effects of histamine on molluscan neurons

Brain Research
T GotowT Tomita

Abstract

Histamine elicited depolarization (excitation) in some neurons and hyperpolarization (inhibition) in other neurons of the central nervous system of the marine mollusc, Onchidium verruculatum. The histamine sensitive region was along the axon at some distance from the soma. H1-receptor blockers (SA-97 and mepyramine) suppressed the excitatory (H1) response without affecting the inhibitory (H2) response, while H2-receptor blockers (burimamide and metiamide) suppressed the H2-response without affecting the H1-response. The H1-response was associated with a marked increase in membrane conductance and was blocked by removal of the external Na. The H2-response consisted of a hyperpolarization without much change in conductance, compared with the hyperpolarization of same amplitude produced by glutamate in the same neuron. Passive polarization of the membrane and reduction of Cl concentrations to 1/5-1/25 caused no significant change in H2-response. The H2-response was slightly suppressed in K-free saline. Thus, it seems difficult to account for the hyperpolarization only by an increase in K or Cl conductance. Complete removal of Na and addition of ouabain blocked the H2-response, suggesting a contribution of an electrogenic Na-pump t...Continue Reading

References

Jun 2, 1977·Nature·J D Turner, G A Cottrell
Mar 27, 1975·Nature·D O Carpenter, G L Gaubatz
Aug 15, 1975·Life Sciences·J C Schwartz
Sep 1, 1968·Journal of Neurophysiology·S Nishi, K Koketsu
Aug 1, 1966·British Journal of Pharmacology and Chemotherapy·A S Ash, H O Schild
Feb 1, 1968·British Journal of Pharmacology and Chemotherapy·G A KerkutG N Woodruff
Apr 21, 1972·Nature·J W BlackE M Parsons
Jan 1, 1965·Comparative Biochemistry and Physiology·G A KERKUT, R C THOMAS

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Citations

Jan 1, 1984·Progress in Neurobiology·K S Rózsa
Mar 1, 1987·Archives internationales de physiologie et de biochimie·J M Arnould
Oct 8, 2019·Antioxidants & Redox Signaling·Carlos Henríquez-OlguínThomas E Jensen

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