Excitatory and inhibitory motor reflexes in the isolated guinea-pig stomach

The Journal of Physiology
G W HennigM Costa

Abstract

1. We have described and analysed the movements of the isolated stomach during distension by correlating intragastric pressure with video recordings, and investigated the presence of intrinsic inhibitory and excitatory reflexes. 2. Isolated guinea-pig stomachs, placed in an organ bath, were slowly distended with Krebs solution using a syringe pump via a cannula through the pylorus. The changes in intragastric pressure during cycles of distension were monitored by pressure transducers connected to both oesophageal and pyloric cannulae. The resistivity of the gastric wall (change in pressure with volume, delta P/delta V) and the amplitude and frequency of phasic pressure events were calculated from pressure recordings. 3. The movements of the stomach were also recorded onto videotape. The motion of the gastric wall during distension cycles was analysed to establish the patterns of contractions, their propagation and the distribution of fluid in the stomach. During filling, fluid was preferentially accommodated in the fundus. Propagating (peristaltic) contractions, often starting in the fundus, moved aborally towards the pylorus. The peak of the phasic pressure event was observed when a contraction reached the orad antrum. As it r...Continue Reading

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Citations

Aug 28, 1999·The Journal of Comparative Neurology·S Yuan, S J Brookes
Jan 9, 2001·The Anatomical Record·M SchemannK Michel
May 2, 2002·The Anatomical Record·Helga PfannkucheMichael Schemann
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